Sökning: "Tunicamycin"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet Tunicamycin.

  1. 1. Structural and Functional Studies of Membrane Proteins For Future Development of Antimicrobial Drugs

    Författare :Elin Dunevall; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic acid transporters; SiaT; MraY; Tunicamycin; Antibiotic resistance;

    Sammanfattning : Antibiotic resistance is a world-wide occurring problem which threatens human health. Without development of any new and effective antibiotics, the rapid growth of antibiotic-resistant bacterial infections could put society in a situation resembling the pre-antibiotic era when a simple lung infection could kill a human being. LÄS MER

  3. 2. Plant Calreticulins - isoforms, localization and function

    Författare :Karin Svensson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; arabidopsis thaliana; calcium; isoform; endoplasmic reticulum; chaperone; tunicamycin;

    Sammanfattning : Calreticulin (CRT) is an endoplasmic reticulum (ER)-located protein involved in quality control of newly synthesized proteins as well as in calcium homeostasis of the cell. Most of what is known about CRT arises from studies of mammalian systems. LÄS MER

  4. 3. Studies on N-linked glycosylation in proliferation and viability of normal and tumor cells in vitro

    Författare :Magdalena Carlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; DNA synthesis; IGF-1 receptor; HMG-CoA reductase; lovastatin; mevalonate; N-linked glycosylation; PDGF; SV40-transformation; tumor; tunicamycin.;

    Sammanfattning : A number of studies suggest a critical role of N-linked glycosylation for cellular proliferation. In addition, many transformed and tumor cells have an altered 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and an increased N-linked glycosylation. LÄS MER

  5. 4. Role of dolichyl phosphate, N-linked glycosylation and cell membrane expression of insulin-like growth factor-1 receptor in maintenance of malignant cell growth

    Författare :Anica Dricu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Several studies have demonstrated that mevalonate (MVA) synthesis is required for cell proliferation. The mechanisms underlying MVA-regulated cell growth are still not fully understood. One conceivable mechanism for MVA-dependent cell growth is N-linked glycosylation of growth regulatory proteins. LÄS MER

  7. 5. Plant Calreticulins -Calcium-binding proteins with many functions

    Författare :Anna Christensen; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tobacco; plant; calreticulin; isoforms; Arabidopsis; localization; mouse embryonic fibroblasts;

    Sammanfattning : Endoplasmic reticulum (ER) plays an important role in protein synthesis, folding, maturation and transport of newly synthesized proteins, as well as the regulation of cellular Ca2+ homeostasis. A protein that is involved in several of these functions in the ER is calreticulin (CRT), which is a Ca2+-binding chaperone that resides in the lumen of the ER. LÄS MER