Sökning: "ribosomal DNA"

Visar resultat 6 - 10 av 69 avhandlingar innehållade orden ribosomal DNA.

  1. 6. Climbing the Trichoptera Tree : Investigations of Branches and Leaves

    Författare :Tobias Malm; Kjell Arne Johanson; Wolfram Mey; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Trichoptera; Leptoceridae; Symphitoneuria; Gracilipsodes; Triplectides; morphology; DNA; systematics; phylogeny; New Caledonia; Madagascar; new species; new genus; Systematics and phylogenetics; Systematik och fylogeni; Systematic Zoology; zoologisk systematik och evolutionsforskning;

    Sammanfattning : The Trichoptera (caddisflies) is the largest of the primary aquatic insect orders, currently including more than 13,500 species. With more than 100 species new to science described annually, the known caddisfly diversity is rapidly increasing. In the first four papers of this Thesis, a total of 22 species new to science are described. LÄS MER

  3. 7. Genomic and transcriptomic sequencing in chronic lymphocytic leukemia

    Författare :Diego Cortese; Richard Professor; Carlos López Otín; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic; lymphocytic; leukemia; CLL; genomics; transcriptomics; DNA; RNA; mutations; NGS; whole-exome; sequencing; prognostic; markers; TP53; SF3B1; RPS15; relapse; stereotyped; subsets.;

    Sammanfattning : Identification of recurrent mutations through next-generation sequencing (NGS) has given us a deeper understanding of the molecular mechanisms involved in chronic lymphocytic leukemia (CLL) development and progression and provided novel means for risk assessment in this clinically heterogeneous disease. In paper I, we screened a population-based cohort of CLL patients (n=364) for TP53, NOTCH1, SF3B1, BIRC3 and MYD88 mutations using Sanger sequencing, and confirmed the negative prognostic impact of TP53, SF3B1 or NOTCH1 aberrations, though at lower frequencies compared to previous studies. LÄS MER

  4. 8. NMR studies of DNA/RNA-binding proteins

    Författare :Helena Berglund; KTH; []
    Nyckelord :;

    Sammanfattning : This thesis concerns the structure and internal dynamics inDNA and RNA-binding proteins. While it has long been known thata proper three-dimensional structure is essential for aprotein's ability to interact with other biomolecules, theinfluence of the inherent protein dynamics is less wellunderstood. LÄS MER

  5. 9. Pathogenic mechanisms affecting mitochondrial DNA replication and transcription

    Författare :Meenakshi Singh; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mtDNA; ribonucleotides; nucleoside analogues; POLRMT;

    Sammanfattning : Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to drive a multitude of cellular reactions. LÄS MER

  7. 10. Silencing and DNA double-strand break repair in budding yeast

    Författare :Andreas Kegel; Stefan Åström; Stephan Marcand; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Silencing; Reb1; DSB; NHEJ; Nej1; illegitimate recombination; yeast; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Transcriptional silencing that makes large chromosomal domains inaccessible for the transcriptional apparatus is nucleated at DNA elements called silencers. In K.lactis a 102bp HMLα silencer was defined revealing three distinct protein-binding regions (A, B, and C) that were required for silencing of HMLα. LÄS MER