Sökning: "illegitimate recombination"

Hittade 3 avhandlingar innehållade orden illegitimate recombination.

  1. 1. Environmental Contaminants, Recombination and Cancer : Investigations on the molecular mechanisms of spontaneous and induced recombination in the hprt gene of Chinese hamster cells

    Författare :Thomas Helleday; Mark Meuth; Stockholms universitet; []
    Nyckelord :toxikologisk genetik; Genetic Toxicology;

    Sammanfattning : Recombination results in rearrangement of the genetic material contained in the chromosomes inherited from the mother and father and this process is also involved in repairing damage to the genome. Occasionally, the machinery that performs recombination malfunctions and this may lead to illegitimate recombination events which inactivate tumor suppressor genes or activate protooncogenes. LÄS MER

  3. 2. Silencing and DNA double-strand break repair in budding yeast

    Författare :Andreas Kegel; Stefan Åström; Stephan Marcand; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Silencing; Reb1; DSB; NHEJ; Nej1; illegitimate recombination; yeast; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Transcriptional silencing that makes large chromosomal domains inaccessible for the transcriptional apparatus is nucleated at DNA elements called silencers. In K.lactis a 102bp HMLα silencer was defined revealing three distinct protein-binding regions (A, B, and C) that were required for silencing of HMLα. LÄS MER

  4. 3. Characterization of Budding Yeast Nonhomologous End-Joining at DNA Double-Strand Breaks and Telomeres

    Författare :Sidney Carter; Stefan Åström; Ed Louis; Stockholms universitet; []
    Nyckelord :DNA repair; nonhomologous end-joining; double-strand break; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : The yeast K. lactis efficiently integrates DNA by illegitimate recombination (IR). IR was completely dependent upon nonhomologous end-joining (NHEJ). In contrast to S. LÄS MER