Sökning: "renin-angiotensin"

Visar resultat 31 - 35 av 69 avhandlingar innehållade ordet renin-angiotensin.

1. 31. High Blood Pressure in Children with Hydronephrosis

   Författare :Ammar Nadhom Farman Al-Mashhadi; Mattias Carlström; Gundela Holmdahl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood pressure; hydronephrosis; hypertension; ambulatory blood pressure monitoring; nitric oxide; oxidative stress; pelvo-ureteric junction obstruction.; Barnkirurgi; Pediatric Surgery;

   Sammanfattning : The most common cause of secondary hypertension is intrinsic renal disease, but little is known about the influence of hydronephrosis on blood pressure. In this thesis, the risk of development of hypertension in children with hydronephrosis was studied. LÄS MER

3. 32. Ligands of the Angiotensin II Type 2 Receptor : Exploring structure and function of the AT2R ligand C38

   Författare :Rebecka Isaksson; Mats Larhed; Annette Bayer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiotensin II type 2 receptor; AT2R antagonists; sulfonyl carbamates; bicyclic amides; metabolic stability; functional activity assay; pharmacological profile; medicinal chemistry; structure-activity relationship; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : The renin-angiotensin-aldosterone-system (RAAS) control blood-pressure regulation, exerted by the main effector peptide angiotensin II (AngII) binding the angiotensin II type 1 receptor (AT1R). While hypertension is the most known disease caused by over-activity in RAAS, several proteins in the system exhibit protective functions. LÄS MER

4. 33. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor

   Författare :Jens Lindman; Mats Larhed; Johan Gising; Christian Sköld; Alessandra Tolomelli; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Mizoroki-Heck reaction; spiroindolines; spirooxindoles; amino acids; carbonylation; angiotensin II type 2 receptor; AT2R ligands; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. LÄS MER

5. 34. Atrial Fibrillation in the setting of Coronary Artery Disease : Risks and outcomes with different treatment options

   Författare :Gorav Batra; Jonas Oldgren; Gunnar Gislason; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atrial fibrillation; coronary artery disease; acute coronary syndrome; myocardial infarction; percutaneous coronary intervention; coronary artery bypass grafting; antithrombotic therapy; angiotensin-converting enzyme inhibitors; angiotensin II receptor blockers; epidemiology; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Coronary artery disease (CAD) is the leading cause of mortality worldwide and atrial fibrillation (AF) is a prevalent arrhythmia associated with increased risk of mortality and morbidity. Despite improved outcome in both diseases, there is a need to further describe the prevalence, outcome and management of CAD in patients with concomitant AF. LÄS MER

7. 35. Clinical studies in severe heart failure : neurohormonal, electrolyte and metabolic aspects

   Författare :Mats Broqvist; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Congestive heart failure is a common and complex syndrome with a poor prognosis. Although heart disease is usually the primary event, the clinical syndrome is characterised by several extra-cardiac manifestations. Neurohormonal activation seems to play a crucial role for these manifestations and the progression of the disease. LÄS MER