Sökning: "nicotinic acid"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden nicotinic acid.

  1. 1. Modelling of tolerance and rebound in normal and diseased rats

    Författare :Christine Ahlström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :feedback modelling; tolerance; rebound; pharmacokinetics; pharmacodynamics; dyslipidaemia; nicotinic acid; non-esterified fatty acids;

    Sammanfattning : The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. LÄS MER

  2. 2. Conditional and non-conditional reward-related responses to alcohol. Nicotinic mechanisms

    Författare :Elin Löf; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ethanol; nicotine; ventral tegmental area; nucleus accumbens; dopamine; nicotinic acetylcholine receptor; gamma-amino-butyric acid receptor A; conditioned reinforcement; in vivo microdialysis; rat;

    Sammanfattning : The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine receptors (nAChRs) within this system appear important for the pharmacological actions of both alcohol and nicotine, which may explain the frequent co-abuse of these two drugs. LÄS MER

  3. 3. Studies on potential hypolipidemic agents : synthesis and biological evaluation of aryloxyacetic acid derivatives, pro-drugs of nicotinic acid and aliphatic aminoalcohols

    Författare :Göran Bondesson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  4. 4. Optimizing nicotinic acid delivery for durable antilipolysis and improved metabolic control

    Författare :Tobias Kroon; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Type 2 diabetes is a devastating disease affecting hundreds of millions worldwide. Lipid accumulation in peripheral non-adipose tissues is a major driver of insulin resistance, a central pathophysiological defect of this disease. LÄS MER

  5. 5. Lipolysis in rabbit, dog and human adipose tissue : effects of noradrenaline, ACTH, theophylline, nicotinic acid, prostaglandin E1 and age

    Författare :Horace Micheli; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER