Sökning: "quinine"

Visar resultat 11 - 15 av 22 avhandlingar innehållade ordet quinine.

  1. 11. Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity

    Författare :Martijn Manson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing and potential new therapies for asthma. LÄS MER

  3. 12. Spectroelectrochemistry of Redox Enzymes

    Författare :Andreas Christenson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Elektrokemi; Electrochemistry; complex II; bilirubin oxidase; laccase; enzyme mechanism; redox potential; electron transfer; spectroelectrochemistry; redox enzymes; Spectroelectrochemical cell;

    Sammanfattning : A low volume and long optical path spectroelectrochemical cell was constructed and tested in a number of applications such as detection of direct electron transfer (DET) between redox enzymes and gold electrodes, determination of the formal potentials of redox centres in proteins and enzymes, as well as mechanistic studies of heterogeneous and intermolecular electron transfer of copper oxidases and succinate:quinine oxidoreductase (Complex II). The existence of DET between enzymes and electrodes was demonstrated for theophylline oxidase, cytochrome P450 cam, laccase, bilirubin oxidase, sulphite oxidase and Complex II. LÄS MER

  4. 13. Aspects of molecular markers in drug resistant malaria

    Författare :Irina Tatiana Jovel Quiñonez Dalmau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : BACKGROUND: There were an estimated 207 million cases of malaria in 2012 of which 91% were due to Plasmodium falciparum. Antimalarial drug resistance constitutes a major problem in the efforts to control malaria. LÄS MER

  5. 14. Taste Hedonics and the Intake of Alcohol and Food

    Författare :Anna Söderpalm; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Alcohol drinking; Adrenalectomy; Corticosterone; Cyanoketone; Food intake; Food restriction; GABA; Metyrapone; Taste reactivity; Benzodiazepine; Chlordiazepoxide; Cis Z -flupentixol; Diazepam; Flumazenil; Microinjections; Midazolam; Nucleus of the Solitary tract; Palatability; Parabrachial nucleus; Peduculopontine Tegmental Nucleus; Reward; 4th ventricle.;

    Sammanfattning : This thesis includes four papers based on animal experimental work. They analyze the way in which activation of a specific motivational state - hunger- modulates the rewarding actions of alcohol and taste palatability. LÄS MER

  7. 15. Pharmacodynamic interactions of quinolines with other antimalarial compounds in vitro

    Författare :Shelton Tendai Mariga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malaria; synergy; combination therapy; Plasmodium falciparum; amodiaquine; lumefantrine; resistance; pharmacodynamics;

    Sammanfattning : Chemotherapy remains the most reliable means for the control of Plasmodium falciparum malaria. Unfortunately the parasite has been able to develop resistance to the majority of the antimalarials currently employed. LÄS MER