Sökning: "pseudovirus."

Hittade 5 avhandlingar innehållade ordet pseudovirus..

  1. 1. Targeting HIV-1 entry and reverse transcription by vaccination

    Författare :Bartek Zuber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; DNA vaccination; coreceptor; CCR5; RT; drug resistance; CpG; pseudovirus;

    Sammanfattning : Human immunodeficiency virus type I (HIV-1) is a complex retrovirus, which uses the CD4 receptor and chemokine receptors to infect its target cells. The chemokine receptor CCR5 is essential for primary HIV-1 infection. The hallmark of retroviruses is the enzyme reverse transcriptase (RT), which transcribes the virus genome from RNA to DNA. LÄS MER

  3. 2. Variable viral genes as genetic immunogens

    Författare :Karl Ljungberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Influenza; hemagglutinin; HIV-1; gp160; DNA vaccine; genetic immunization; CpG; GM-CSF; pseudovirus.;

    Sammanfattning : Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost-effective medical intervention against influenza is vaccination but this has to be repeated annually because of the low antigenicity of the vaccine. LÄS MER

  4. 3. Human papillomavirus tropism : determinants of viral tissue specificity

    Författare :Nitesh Mistry; Magnus Evander; Ola Forslund; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; papillomavirus; receptor; heparan sulfate; pI; lactoferrin; lactoferricin; transcription; long control region; tropism; Virology; Virologi;

    Sammanfattning : Cervical cancer is the second most common cancer among women worldwide and human papillomavirus (HPV) is a prerequisit for the development of this cancer. HPV belongs to the Papillomaviridae family and infects the basal layer of epithelial cells where it generally progresses into warts or condylomas. LÄS MER

  5. 4. Natural killer cells and antibody-mediated effects in human immunodeficiency virus infection

    Författare :Susanne Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human immunodeficiency virus (HIV-1) effectively avoids immunologic eradication. Certain characteristics of the virus contribute to this, including the specific targeting of the body s own defense system, the ability to hide in the host cell genome and the vast viral variability. LÄS MER

  7. 5. Regulation of gene and protein expression : two model systems

    Författare :Lars H Lund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; EIAV; Tat; TAR; Cyclin T1; CDK9; P-TEFb; RNA polymerase II; gene regulation; transcriptional elongation; CEA; signal sequence.;

    Sammanfattning : Genetic information is expressed by DNA transcription and mRNA translation. With few exceptions, every cell of an organism, or the human body, contains the same genetic information. Yet the structure and function of different tissues are highly variable. LÄS MER