Sökning: "CCR5"
Visar resultat 1 - 5 av 64 avhandlingar innehållade ordet CCR5.
1. Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
Sammanfattning : The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of infected individuals. LÄS MER
2. Virus tropism and neutralization response in SIV infection
Sammanfattning : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. LÄS MER
3. HIV-1 patient assessment and treatment : from multitest to co-receptor (CCR5) gene polymorphism : from Rgp160 immunization to highly active antiretroviral treatment (HAART)
Sammanfattning : During the last 15 years, understanding of the pathogenesis of HIV- 1 infection and AIDS has developed rapidly. From a mysterious plague-like untreatable disease with unknown cause and transmission route to a well characterized, chronic, manageable, if yet not curable, retroviral infection. LÄS MER
4. Targeting HIV-1 entry and reverse transcription by vaccination
Sammanfattning : Human immunodeficiency virus type I (HIV-1) is a complex retrovirus, which uses the CD4 receptor and chemokine receptors to infect its target cells. The chemokine receptor CCR5 is essential for primary HIV-1 infection. The hallmark of retroviruses is the enzyme reverse transcriptase (RT), which transcribes the virus genome from RNA to DNA. LÄS MER
5. Viral parameters influencing clinical long-term non progression in HIV-1 infected subjects
Sammanfattning : A very small portion of the HIV-1 infected population is constituted by individuals, called long- term non progressors (LTNP), in whom after even a decade or more, no visible deterioration of the immune system is recognized and the infection remains therefore asymptomatic. The reasons for such "natural" prolonged well-being can be attributed to both the virus and the infected host and their understanding is likely to give important information for the development of an effective HIV- vaccine and for immune reconstitution therapy. LÄS MER