Avancerad sökning

Visar resultat 11 - 15 av 93 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. Unlocking protein sequences : Advances in protein structure and ligand-binding site prediction

    Författare :Aditi Shenoy; Arne Elofsson; Geoffrey J Barton; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Sammanfattning : The protein sequence determines how it will fold into its unique three-dimensional structure. Once folded, proteins perform their functions by interacting with other proteins or molecules called ligands within the cell. Experimental determination of protein structure and function is tedious. LÄS MER

  2. 12. Structural Information and Hidden Markov Models for Biological Sequence Analysis

    Författare :Jeanette Tångrot; Bo Kågström; Uwe H. Sauer; Erik Sonnhammer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HMM; structure alignment; protein structure; secondary structure; remote homologue; annotation; domain family; protein family; protein superfamily; protein fold recognition; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatics is a fast-developing field, which makes use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins, which is often based on finding relationships to already characterized proteins. LÄS MER

  3. 13. Prediction, modeling, and refinement of protein structure

    Författare :Per Larsson; Arne Elofsson; Erik Lindahl; Barry Honig; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein structure prediction; Multiple alignments; Quality assessment; Molecular dynamics; Implicit solvent; Refinement; Bioinformatics; Bioinformatik; Bioinformatics; Bioinformatik; Statistical mechanics; Statistisk mekanik; Biochemistry; biokemi;

    Sammanfattning : Accurate predictions of protein structure are important for understanding many processes in cells. The interactions that govern protein folding and structure are complex, and still far from completely understood. However, progress is being made in many areas. Here, efforts to improve the overall quality of protein structure models are described. LÄS MER

  4. 14. A Dance with Protein Assemblies : Analysis, Structure Prediction, and Design

    Författare :Mads Jeppesen; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein design; protein structure prediction; virus assembly;

    Sammanfattning : Protein assemblies are some of the most complex molecular machines in nature. They facilitate many cellular functions, from DNA replication to molecular motion, energy production, and even the production of other proteins. LÄS MER

  5. 15. Learning Protein Evolution and Structure

    Författare :Patrick Bryant; Arne Elofsson; Paul Bates; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein structure prediction; Evolution; AI; AlphaFold; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Sammanfattning : By analysing the structure of a protein it is possible to draw conclusions about its function. Obtaining the structure of a protein experimentally is however a time consuming and expensive process. By using evolution it is possible to infer the structure of a protein. LÄS MER