Sökning: "protein dynamics"

Visar resultat 26 - 30 av 487 avhandlingar innehållade orden protein dynamics.

  1. 26. Determining the effects of regulatory parameters on the structural dynamics of P-type ATPase membrane transporters

    Författare :Fredrik Orädd; Magnus Andersson; Magnus Wolf-Watz; Marco Cammarata; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein dynamics; regulation; time-resolved x-ray solution scattering; MD simulation; membrane protein; P-type ATPase; SERCA; CopA; HMA4; adenylate kinase; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : Proteins are macromolecular machines with roles in all cellular activities and structures. The functional properties of each protein is the result of its combination of 3D-structure and inherent dynamics, and a wealth of structural and dynamic mechanisms have evolved to regulate protein activity. LÄS MER

  3. 27. Protein-Surfactant Interactions in Complex Systems : Study of Physical Stability of Proteins and Peptides

    Författare :Johanna Hjalte; Avdelningen för livsmedel och läkemedel; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; therapeutic proteins; NMR nuclear magnetic resonance ; physical stability; surfactant protein interaction; preservative protein interaction; peptide aggregation;

    Sammanfattning : My objective has been to characterize protein-surfactant interactions in pharmaceutically relevant formulations. Thus, the behavior of selected excipients, proteins and peptides has been studied as the system in question is driven to the verge of instability in different manners; by inducing aggregation, by inducing surfactant complexation, or by inducing precipitation by increasing ionic strength in the presence of preservative. LÄS MER

  4. 28. The Role of Sugars for Protein Stabilization

    Författare :Christoffer Olsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein; water; QENS; biomolecule; EPSR; amorphous; trehalose; neutron scattering; cryopreservation; DSC; neutron diffraction; dielectric spectroscopy;

    Sammanfattning : The understanding of biomolecular interactions with water and co-solutes can lead to greater knowledge regarding the mechanisms behind biomolecular stabilization. This is highly important for developing technologies aimed to preserve biological materials. LÄS MER

  5. 29. Mutational effects on protein structure and function

    Författare :Jonas Carlsson; Persson Bengt; Uwe Sauer; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mutation; prediction; phenotypes; homology model; virtual screening; molecular dynamics; amyloid; cancer; membrane protein; Bioinformatics; Bioinformatik;

    Sammanfattning : In this thesis several important proteins are investigated from a structural perspective. Some of the proteins are disease related while other have important but not completely characterised functions. LÄS MER

  7. 30. Hierarchical Assembly Investigations and Multiscale Characterization of Protein-based Materials : Insights from Whey Protein Nanofibrils and Recombinant Spider Silk Microspheres

    Författare :Eirini Ornithopoulou; My Hedhammar; Thomas Crouzier; Christina Divne; Tim Melander Bowden; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hierarchical Assembly; Protein-based materials; Whey Protein Nanofibrils; β-Lactoglobulin; Recombinant Spider Silk; Microspheres; Biomedical Applications; Surface Biofunctionalization; Hierarkisk montering; Proteinbaserade material; Vassleprotein nanofibriller; β-Laktoglobulin; Rekombinant spindelsilke Mikrosfärer; Biomedicinska tillämpningar; Ytbiokonjugering; Biotechnology; Bioteknologi;

    Sammanfattning : Protein-based materials, with their unique properties of combining high strength, while maintaining elasticity, and their inherent biocompatibility, hold immense potential for various applications. In order to harness these properties, we need to understand and control how protein building blocks come together to form hierarchically structured materials. LÄS MER