Sökning: "protein dynamics"

Visar resultat 21 - 25 av 485 avhandlingar innehållade orden protein dynamics.

1. 21. An evolutionary basis for protein design and structure prediction

   Författare :Christoffer Norn; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein evolution; Biophysics; Protein design; Protein structure prediction;

   Sammanfattning : The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design new protein functions. LÄS MER

3. 22. Molecular dynamics studied by NMR relaxation experiments. Characterization of functional dynamics in the FK506 binding protein FKBP12

   Författare :Ulrika Brath; Biofysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nuclear magnetic resonance; NMR; FK506; protein dynamics; chemical exchange; spin relaxation; FKBP12; FKBP; isotope labeling;

   Sammanfattning : The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. LÄS MER

4. 23. Computational Prediction and Analysis of Protein-Carbohydrate and Protein-Protein Interactions

   Författare :Ashok Krishna Chaitanya Koppisetty; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Arylsulfatase-A; Norovirus VA387; Molecular Dynamics; Saposin B; Computational Docking;

   Sammanfattning : The structure and energetics of protein-carbohydrate and protein-protein interactions are of great interest due to their importance in many biological phenomena. Two cases of protein-carbohydrate interactions and one case of protein-protein interactions were predicted and analyzed using existing computational methods. LÄS MER

5. 24. Modelling the Protein-DNA Interface

   Författare :Malin Lüking; Shina C. Lynn Kamerlin; Ehmke Pohl; Uppsala universitet; []
   Nyckelord :Protein-DNA interactions; Molecular Dynamics; Coarse-grained simulations; gene regulation; Biokemi; Biochemistry;

   Sammanfattning : Protein-DNA interactions are crucial to life. Several millions of DNA base pair steps are organ- ised, read and protected by proteins in every cell. Protein-DNA interactions must be specific, controllable and reasonably fast. Understanding how these features coexist is one of the great challenges for biochemists and molecular biologists. LÄS MER

7. 25. Protein Folding and DNA Origami

   Författare :Mark Marvin Seibert; David van der Spoel; Helmut Grubmüller; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; Molecular Dynamics simulations; DNA origami; Biophysics; Biofysik; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

   Sammanfattning : In this thesis, the folding process of the de novo designed polypeptide chignolin was elucidated through atomic-scale Molecular Dynamics (MD) computer simulations. In a series of long timescale and replica exchange MD simulations, chignolin’s folding and unfolding was observed numerous times and the native state was identified from the computed Gibbs free-energy landscape. LÄS MER