Sökning: "pindolol"

Hittade 4 avhandlingar innehållade ordet pindolol.

  1. 1. Stereoselective Transport of Drugs Across the Blood-Brain Barrier (BBB) In Vivo and In Vitro : Pharmacokinetic and Pharmacodynamic Studies of the (S)- and (R)-Enantiomers of Different 5-HT1A Receptor Agonists and Antagonists

    Författare :Hongmei Yan; Lennart Paalzow; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; pindolol; propranolol; 2- di-n-propylamino tetralin; racemate; enantiomer; drug distribution; brain; rat; blood-brain barrier; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Sammanfattning : Delivery of drugs to the brain requires passage across the blood-brain barrier (BBB). Both for drugs already on the market and for new drugs under development, it is important to know to what extent a drug enters the CNS. Many drugs used clinically are racemic mixtures, i.e. LÄS MER

  3. 2. Positron emission tomography in serotonergic drug development

    Författare :Bengt Andrée; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; 5-HT1A receptors; 5-HT2A receptors; D2 dopamine receptors; antidepressive drugs; antipsychotic drugs; pindolol; NAD-299; S 16924; ORG 5222; M100907; WAY; DWAY;

    Sammanfattning : The serotonin neurotransmission system has a central role in drug treatment of depression and anxiety and is also discussed in relation to treatment of schizophrenia. The benefits of presently available drugs are however limited by partial of poor response and side effects. LÄS MER

  4. 3. Noradrenergic augmentation strategies in the pharmacological treatment of depression and schizophrenia : an experimental study

    Författare :Love Linnér; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pharmacological treatment of depression and schizophrenia, two major psychiatric disorders, is largely based on modulation of central monoaminergic neurotransmission. However, currently available pharmacological treatment alternatives possess a relatively modest clinical efficacy, making them less than optimal. LÄS MER

  5. 4. Bronchial hyperresponsiveness of ß-adrenoceptor agonists and antagonists in guinea pig airways

    Författare :Fredrik Johansson; Sven-Erik Dahlén; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Asthma is one of the most common diseases in the industrialised countries. The underlying mechanisms are complex and still not fully understood although inflammation of the airways plays an important role. LÄS MER