Sökning: "M100907"

Hittade 3 avhandlingar innehållade ordet M100907.

  1. 1. Clinical molecular imaging of schizophrenia

    Författare :Mirjam Talvik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; D2 D3 receptors; 5HT2A receptors; antipsychotic drugs; schizophrenia; age effects; raclopride; FLB 457; M100907; clozapine; haloperidol; perphenazine; thalamus; cortex; striatum; PANSS;

    Sammanfattning : The aim of this thesis was to examine pathophysiology and antipsychotic treatment of schizophrenia by using positron emission tomography (PET). The high affinity radioligand [11C]FLB 457 was used for determination of dopamine D2 receptor binding in the thalamus and the cortex of nine drug-naïve patients with schizophrenia and eight control subjects. LÄS MER

  3. 2. Positron emission tomography in serotonergic drug development

    Författare :Bengt Andrée; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; 5-HT1A receptors; 5-HT2A receptors; D2 dopamine receptors; antidepressive drugs; antipsychotic drugs; pindolol; NAD-299; S 16924; ORG 5222; M100907; WAY; DWAY;

    Sammanfattning : The serotonin neurotransmission system has a central role in drug treatment of depression and anxiety and is also discussed in relation to treatment of schizophrenia. The benefits of presently available drugs are however limited by partial of poor response and side effects. LÄS MER

  4. 3. Movement pattern analysis of hypoglutamatergic mice. A model for cognitive deficits of schizophrenia and autism?

    Författare :Marie Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; autism; cognition; movement pattern; video tracking; MK-801; mice;

    Sammanfattning : Schizophrenia and autism are two severe neuropsychiatric disorders that are associated withprofound cognitive disturbances which considerably contribute to the long-term morbidity andthe decreased ability to function in the society. Currently used therapies do not reach the corecognitive disturbances to a satisfactory extent. LÄS MER