Sökning: "pharmacogenetics"

Visar resultat 21 - 25 av 41 avhandlingar innehållade ordet pharmacogenetics.

  1. 21. Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians

    Författare :Eleni Aklillu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; gene duplication; CYP2D6; CYP2C19; CYP2C9; CYP1B1; CYP1A2; genotyping; xanthine oxidase; ultrarapid metabolizers; polymorphism; caffeine; Ets; dietary selection.;

    Sammanfattning : Pharmacogenetics of drug metabolising enzymes has been well studied in Caucasians and Asians, but relatively little in Africans. The aim of this thesis was to investigate the molecular genetics of drug metabolising enzymes, in particular CYP2D6, CYP2C19, CYP2C9, CYP1B1, CYP1A2 and XO, with special emphasis on the Ethiopian population. LÄS MER

  3. 22. CYP2C19 and CYP2C9 : new aspects of pharmacogenetics and transcriptional regulation

    Författare :Jessica Mwinyi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to significantly affect the individual drug response. LÄS MER

  4. 23. Optimization of HIV and tuberculosis co-treatment in Tanzanian patients : emphasis on pharmacogenetics and drug interactions

    Författare :Eliford Ngaimisi Kitabi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Treatment of HIV and its comorbidities particularly tuberculosis is complicated by wide inter-individual variations in drug exposure due to drug-interactions and variable expressions of drug metabolizing enzymes and transporters. Efavirenz in particular, is an antiretroviral characterized by wide inter-individual variation in exposure. LÄS MER

  5. 24. HIV treatment outcomes in Uganda : the impact of baseline characteristics and variability in pharmacokinetics and pharmacogenetics of antiretroviral drugs

    Författare :Sarah Nanzigu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ART Outcomes;

    Sammanfattning : Guidelines specify criteria for initiation and monitoring of antiretroviral treatment (ART), including options for first line regimens. Immunological progress remains a widely used form of HIV/ART monitoring and efavirenz, a preferred first line antiretroviral drug. LÄS MER

  7. 25. Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population

    Författare :Agneta Wennerholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; cytochrome P450; polymorphism; pharmacogenetics; genotyping; phenotyping; CYP2D6; CYP3A; debrisoquine; amodiaquine; alprazolam;

    Sammanfattning : The cytochrome P450 (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes. Both genetic and environmental factors such as concomitant drug use and concurrent diseases influence the activities of these enzymes. LÄS MER