Sökning: "pharmacogenetics"

Visar resultat 36 - 40 av 41 avhandlingar innehållade ordet pharmacogenetics.

  1. 36. Studies on the clinical pharmacology of antiretroviral agents

    Författare :Filip Josephson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis begins with an account of the development of the antiretroviral treatment paradigm for HIV infection, focusing on the emergence of present day principles of antiretroviral therapy (e.g. LÄS MER

  3. 37. Genetic influence on enantiomeric drug disposition : Focus on venlafaxine and citalopram

    Författare :Maria Kingbäck; Fredrik Kugelberg; Björn Carlsson; Martin Josefsson; Finn Bengtsson; Johan Ahlner; Anders Rane; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : A molecule that is not identical to its mirror image is said to be chiral. A racemic mixture, or a racemate, is one that has equal amounts of S- and R-enantiomers of a chiral molecule. Two examples of frequently prescribed racemic drugs are the antidepressants venlafaxine (VEN) and citalopram (CIT). LÄS MER

  4. 38. Clinical studies on drug treatment of hospitalised patients : general infectious diseases and acute myocardial infarction

    Författare :Ksenia Zagorodnikova; Ksenia Goryachkina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Treatment of hospitalised patients is generally governed by the pre-developed algorithms and common guidelines. These approaches are helpful in most, but not all cases. Treatment of hospitalised patients is limited to the time of hospital stay and is therefore directed to immediate help. LÄS MER

  5. 39. Pharmacovigilance capacity in East Africa with focus on neglected tropical diseases

    Författare :Abbie Barry; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pharmacovigilance aims to enhance patient safety in relation to the use of medicines by reducing the incidence and severity of adverse events which includes supporting public health programs by providing information on the safety profile of medicines used by the programs. In Africa, the increased access to medicinal products is not well-matched with the pharmacovigilance capacity to monitor drug safety. LÄS MER

  7. 40. Novel combination chemotherapy for treatment and control of schistosomiasis among school children

    Författare :Rajabu Hussein Mnkugwe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite reported success in reducing severe disease-associated morbidities in endemic countries, praziquantel (PZQ) alone has failed to control and eliminate schistosomiasis, partly due to its poor efficacy against immature/juvenile worms. Artemisinin derivatives are efficacious against juvenile schistosomes. LÄS MER