Sökning: "pharmacogenetics"
Visar resultat 16 - 20 av 41 avhandlingar innehållade ordet pharmacogenetics.
16. Optimization of cyclophosphamide therapy based on pharmacogenetics
Sammanfattning : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. LÄS MER
17. Forensic Toxicological Aspects of Tramadol : Focus on Enantioselective Drug Disposition and Pharmacogenetics
Sammanfattning : One of the most difficult parts in forensic toxicology is to interpret obtained drug concentrations. Was it therapeutic, toxic or even lethal to the particular individual that the blood sample was drawn from? Concentrations of opioid drugs are especially difficult to interpret, because of large interindividual differences in innate and acquired tolerance. LÄS MER
18. Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes
Sammanfattning : The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to drug metabolism, in particular CYP3A4. responsible for the metabolism of a majority of drugs being metabolized in order to be excreted. LÄS MER
19. Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy
Sammanfattning : There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce adverse drug reactions and contribute to the development of personalized medicine. LÄS MER
20. Cardiovascular risk factors and pharmacogenetics of clozapine in schizophrenia
Sammanfattning : Background: Severe mental illness, including schizophrenia is associated with an increased risk of premature death by somatic conditions and in particular by cardiovascular events. Reducing cardiovascular risk factors in patients with psychotic disorder is urgently called for. LÄS MER