Sökning: "periventricular white matter"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden periventricular white matter.

  1. 1. Cerebral intraventricular hemorrhage and post-hemorrhagic ventricular dilatation in preterm infants: new mechanistic insights and potential treatment strategies

    Författare :Olga Romantsik; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prematurity; Intraventricular hemorrhage; Post-hemorrhagic ventricular dilatation; White matter injury; Gray matter injury; Preterm rabbits; Extracellular hemoglobin; a-1-microglobulin; animal IVH models; High frequency ultrasound; MRI; corticogenesis;

    Sammanfattning : Intraventricular hemorrhage (IVH) is one of the major co-morbidities of premature birth associated with post-hemorrhagic ventricular dilatation (PHVD) development, long-term neurodevelopmental impairment, behavioral problems, special educational needs, and dependency on social security.Hypothesis and aims: We believe that extravasated blood and further release of extracellular hemoglobin (Hb) are crucial in brain injury following IVH and consequent development of PHVD. LÄS MER

  3. 2. Magnetic resonance imaging in dementia : a study of brain white matter changes

    Författare :Lena Bronge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Non-specific white matter changes (WMC) in the brain are common findings in the elderly population. Although they are frequently seen in non-demented persons, WMC seem to be more common in demented patients.The significance of these changes, as well as their pathophysiological background is incompletely understood. LÄS MER

  4. 3. White matter pathology in normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy. Clinical, CSF and MRI aspects

    Författare :Mats Tullberg; Göteborgs universitet; []
    Nyckelord :Normal pressure hydrocephalus; Subcortical arteriosclerotic encephalopathy; MRI; White matter changes; Cerebrospinal fluid; Sulfatide; Neurofilament protein;

    Sammanfattning : Normal pressure hydrocephalus (NPH) and subcortical arteriosclerotic encephalopathy (SAE) are common causes of gait disturbance, cognitive impairment and urinary incontinence in the elderly. In spite of a primarily different pathogenesis with a potentially reversible CSF dynamic disturbance in NPH and an irreversible microangiopathy in SAE, patients with NPH and SAE can present with similar symptoms and exhibit white matter changes that are difficult to distinguish, constituting a diagnostic and therapeutic challenge. LÄS MER

  5. 4. Pathophysiology of intrauterine asphyxia

    Författare :Anna-Karin Welin; Göteborgs universitet; []
    Nyckelord :asphyxia; ECG; endotoxemia; fetal sheep; inflammation; melatonin; periventricular leukomalacia; preterm;

    Sammanfattning : Background: The premature infant is at increased risk of cerebral white matter damage, oftenreferred to as periventricular leucomalacia, PVL, which is associated with later developmentof cerebral palsy and cognitive impairment. The etiology of PVL remains unclear, but ischemia-reperfusion followed by generation of free radicals and intrauterine infections havebeen suggested to play an important role. LÄS MER

  7. 5. Preterm intraventricular cerebral hemorrhage: role of cell-free hemoglobin

    Författare :Alex Adusei Agyemang; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intraventricular hemorrhage; Preterm birth; Haptoglobin; Alpha 1 microglobulin; cerebellar hypoplasia; periventricular white matter; cell-free hemoglobin;

    Sammanfattning : Cerebral intraventricular hemorrhage in preterm infants continues to be a major clinical problem associated with neurodevelopmental abnormalities manifested by cognitive, behavioral, attentional, social and motor deficits. Hypothesis and aims: The central thesis is that the cytotoxicity of extravasated blood and of consequently released cell-free hemoglobin(Hb) is pivotal for the pathophysiological events causally involved in brain injury. LÄS MER