Sökning: "White matter injury"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden White matter injury.

  1. 1. Fatigue after traumatic brain injury : exploring novel methods for diagnosis and treatment

    Författare :Nils Berginström; Anna Nordström; Peter Nordström; Lars Nyberg; Jan Lexell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; fatigue; OSU6162; randomized clinical trials; functional magnetic resonance imaging; neuropsychology; structural magnetic resonance imaging; white matter hyperintensities; rehabiliteringsmedicin; Rehabilitation Medicine;

    Sammanfattning : Background: Traumatic brain injury (TBI) is one of the most common causes of disability and mortality. While some patients recover quickly, especially at the mild side of the injury severity continuum, many will experience symptoms for years to come. LÄS MER

  3. 2. Cerebral intraventricular hemorrhage and post-hemorrhagic ventricular dilatation in preterm infants: new mechanistic insights and potential treatment strategies

    Författare :Olga Romantsik; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prematurity; Intraventricular hemorrhage; Post-hemorrhagic ventricular dilatation; White matter injury; Gray matter injury; Preterm rabbits; Extracellular hemoglobin; a-1-microglobulin; animal IVH models; High frequency ultrasound; MRI; corticogenesis;

    Sammanfattning : Intraventricular hemorrhage (IVH) is one of the major co-morbidities of premature birth associated with post-hemorrhagic ventricular dilatation (PHVD) development, long-term neurodevelopmental impairment, behavioral problems, special educational needs, and dependency on social security.Hypothesis and aims: We believe that extravasated blood and further release of extracellular hemoglobin (Hb) are crucial in brain injury following IVH and consequent development of PHVD. LÄS MER

  4. 3. Oligodendrocyte pathology following Traumatic Brain Injury : Experimental and clinical studies

    Författare :Johanna Flygt; Niklas Marklund; Fredrik Piehl; Uppsala universitet; []
    Nyckelord :Traumatic brain injury; oligodendrocytes; oligodendrocyte progenitor cells; interleukin 1-β; central fluid percussion injury; Neurokirurgi; Neurosurgery; Neurokirurgi; Neurosurgery;

    Sammanfattning : Traumatic brain injury (TBI) caused by traffic and fall accidents, sports-related injuries and violence commonly results in life-changing disabilities. Cognitive impairments following TBI may be due to disruption of axons, stretched by the acceleration/deceleration forces of the initial impact, and their surrounding myelin in neuronal networks. LÄS MER

  5. 4. An animal model of sport related concussive brain injury

    Författare :Hayde Bolouri; Göteborgs universitet; []
    Nyckelord :animal model; football; concussion; brain injury; neuropathology; cognitive function;

    Sammanfattning : A new animal model for concussion of the type seen in professional football was developed, since current animal models did not simulate these conditions. The model is characterized by a high velocity-low mass impact to the head of a freely moving object. Structural damages and functional effects of the model have been investigated. LÄS MER

  7. 5. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER