Sökning: "oral dosage form"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden oral dosage form.
1. Functional Ceramics in Biomedical Applications : On the Use of Ceramics for Controlled Drug Release and Targeted Cell Stimulation
Sammanfattning : Ceramics are distinguished from metals and polymers by their inorganic nature and lack of metallic properties. They can be highly crystalline to amorphous, and their physical and chemical properties can vary widely. LÄS MER
2. New Concepts in Administration of Drugs in Tablet Form : Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System
Sammanfattning : This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. LÄS MER
3. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs
Sammanfattning : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. LÄS MER
Sammanfattning : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. LÄS MER
5. On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios
Sammanfattning : Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is efficacious but the cumbersome intravenous administration leaves numerous patients untreated. LÄS MER