Sökning: "lipid-based formulation"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden lipid-based formulation.
1. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs
Sammanfattning : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. LÄS MER
2. 3D printing of lipid-based formulations into personalized solid oral dosage forms
Sammanfattning : The pharmaceutical development process starts with patient populations and their unmet therapeutic needs. Traditional pharmaceutical manufacturing of solid oral dosage forms is based on the strategy of one-size-fits-all. This is problematic, especially for patient populations with high patient-to-patient variability, as in pediatrics. LÄS MER
3. Predicting oral performance of lipid-based formulations using in vitro methods
Sammanfattning : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. LÄS MER
4. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System
Sammanfattning : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. LÄS MER
5. Lipid based formulations for topical application: characterization and delivery of active substances
Sammanfattning : In this thesis, the interaction between lipids, solvents and active substances in lipid based formulations have been studied and related to formulation structure or release behavior on human skin or a model thereof. For the different investigations, isotropic equilibrium lipid phases, i.e. LÄS MER
