Sökning: "oral dosage form"

Visar resultat 6 - 10 av 13 avhandlingar innehållade orden oral dosage form.

  1. 6. Mechanism-based modeling of biological processes involved in oral absorption

    Författare :Benjamin Guiastrennec; Mats O. Karlsson; Martin Bergstrand; Jörg Lippert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; absorption; bile acids; enterohepatic circulation; food effect; gallbladder; in vitro in vivo correlation; NONMEM; pediatrics; pharmacometrics; tuberculosis; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. LÄS MER

  3. 7. On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios

    Författare :Rasmus Jansson Löfmark; Göteborgs universitet; []
    Nyckelord :Human African trypanosomiasis; HAT; Pharmacokinetics; NONMEM; Stereoselectivity; Eflornithine; Tissue distribution;

    Sammanfattning : Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is efficacious but the cumbersome intravenous administration leaves numerous patients untreated. LÄS MER

  4. 8. Manipulation of medicines, necessary in everyday practice for individualised doses in paediatric care

    Författare :Åsa C. Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Introduction: Manipulation of medicines is often necessary in the paediatric setting due to lack of medicines suitable for paediatric patients. There are previous short-term frequency studies in different paediatric settings, but no long-term studies and no comparison between two different years in the same setting. LÄS MER

  5. 9. Catanionic Aggregates in Gels : Prolonged Drug Release and Potential Implications for Topical Use

    Författare :Noel Dew; Erik Björk; Stefan Ulvenlund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Galenisk farmaci; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : Gels are popular dosage forms.  This topical dosage form may be advantageous compared to oral or parenteral dosage forms. Favorable rheological or bioadhesive properties of gels might provide extended contact times at the site of administration compared to aqueous solutions. LÄS MER

  7. 10. Cyclosporin A-induced gingival overgrowth in renal transplant patients : a clinical, histological and experimental study

    Författare :Biniyam Wondimu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cyclosporin A gingival overgrowth gingival fibroblasts nephrotoxicity renal transplant saliva;

    Sammanfattning : Cyclosporine A (CsA) is widely used as an effective immunosuppressive agent to prevent rejection of organ transplants, as well as in the treatment of patients with various autoimmune diseases. The clinical use of CsA, however, is associated with adverse side effects, including nephrotoxicity, hepatotoxicity, hypertension, and neurotoxicity as well as gingival overgrowth. LÄS MER