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Visar resultat 1 - 5 av 17 avhandlingar som matchar ovanstående sökkriterier.

1. 1. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation

   Författare :Adriane Guillaumin; Åsa Wallén-Mackenzie; Konstantinos Meletis; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Subthalamic nucleus; optogenetics; basal ganglia; locomotion; Parkinson s disease; aversion; Neuroscience; Neurovetenskap;

   Sammanfattning : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. LÄS MER

3. 2. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

   Författare :Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

   Sammanfattning : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). LÄS MER

4. 3. Optogenetic control of spinal microcircuits : insights into locomotor rhythm and pattern generation

   Författare :Martin Hägglund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mammalian locomotion is a complex task in which hundreds of muscles work together in a coordinated fashion. Neural networks in the spinal cord, known as central pattern generators (CPGs), carry all the components necessary to produce the cyclical pattern of muscle activity needed for locomotion. LÄS MER

5. 4. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

   Författare :Fredrik Berglind; Epilepsicentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Seizure; epileptogenesis; optogenetics; NpHR; ChR2; DREADD; hippocampus; in vivo; mouse;

   Sammanfattning : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. LÄS MER

7. 5. Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation

   Författare :Caroline Miranda; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Glucagon; α-Cell; Optogenetics;

   Sammanfattning : ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and explored the spatio-temporal relationship between cell activation and glucagon release. LÄS MER