Sökning: "optogenetic"
Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet optogenetic.
1. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation
Sammanfattning : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. LÄS MER
2. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement
Sammanfattning : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). LÄS MER
3. Optogenetic control of spinal microcircuits : insights into locomotor rhythm and pattern generation
Sammanfattning : Mammalian locomotion is a complex task in which hundreds of muscles work together in a coordinated fashion. Neural networks in the spinal cord, known as central pattern generators (CPGs), carry all the components necessary to produce the cyclical pattern of muscle activity needed for locomotion. LÄS MER
4. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry
Sammanfattning : Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmaceuticals. LÄS MER
5. Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
Sammanfattning : ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and explored the spatio-temporal relationship between cell activation and glucagon release. LÄS MER