Sökning: "nuclear hormone receptor"

Visar resultat 6 - 10 av 80 avhandlingar innehållade orden nuclear hormone receptor.

  1. 6. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    Författare :Emma Jernberg; Pernilla Wikström; Jack Schalken; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

  3. 7. Molecular basis of estrogen receptor antagonism

    Författare :Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

    Sammanfattning : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. LÄS MER

  4. 8. Core Biopsy of Breast and Axillary Lesions : Technical and Clinical Aspects

    Författare :Shahin Abdsaleh; PG Lindgren; Per Skaane; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiology; Automatic core needle biopsy; Semiautomatic core needle biopsy; Surgical specimen; Dynamic needle behavior; Hormone Receptors; Radiologisk forskning; Radiological research; Radiologisk forskning;

    Sammanfattning : The aims of this work were to image and analyze the needle behavior at automated core biopsy, to investigate the clinical utility of an alternative core biopsy technique using a semiautomated gun in breast and axillary lesions, and also to compare core biopsy with surgical specimens in malignant breast lesions regarding histologic features and hormone receptor expression.In two experimental studies, using butter and silicon phantoms, respectively, the needle pass was imaged and its dynamic behavior studied. LÄS MER

  5. 9. Studies in nuclear receptor Nurr1 : identification of Nurr1-regulated genes

    Författare :Elisabet Hermanson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptor family comprises more than sixty members, including receptors for steroids, thyroid hormone and retinoids. Many nuclear receptors function as ligand- activated transcription factors that regulate the expression of specific target genes. LÄS MER

  7. 10. Role of nuclear receptors in the regulation of human adipose tissue metabolism

    Författare :Prasad G. Kamble; Jan W Eriksson; Ingrid Dahlman; Uppsala universitet; []
    Nyckelord :human adipose tissue; nuclear receptors; glucocorticoids; estrogen; PPARγ; lipocalin 2; glucose uptake; lipolysis; adipogenesis; genotype-based recall;

    Sammanfattning : Nuclear receptors modulate expression of genes involved in adipose tissue (AT) metabolism. Their improved understanding may provide new treatment options for metabolic disorders such as obesity, insulin resistance (IR) and type 2 diabetes (T2D). LÄS MER