Sökning: "PPARγ"
Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet PPARγ.
1. Role of nuclear receptors in the regulation of human adipose tissue metabolism
Sammanfattning : Nuclear receptors modulate expression of genes involved in adipose tissue (AT) metabolism. Their improved understanding may provide new treatment options for metabolic disorders such as obesity, insulin resistance (IR) and type 2 diabetes (T2D). LÄS MER
2. WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance
Sammanfattning : Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin resistance, defined as an impaired cellular effect of insulin, and this precedes the development of T2D. LÄS MER
3. Transcriptional activity of PPARγ in primary human adipocytes
Sammanfattning : The prevalence of obesity is increasing in most parts of the world and is a strong risk factor for the development of insulin resistance, type 2 diabetes and hypertension. Adipose tissue is mainly composed of adipocytes which store energy in the form of triglycerides and release it as free fatty acids. LÄS MER
4. Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation
Sammanfattning : Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate transcriptional responses of the genome. LÄS MER
5. The microbiome, PPARγ and AhR in the inflammation-metabolism interface within the gastrointestinal tract
Sammanfattning : The mammalian body is a mosaic of different organisms - a holobiont, which contains all the biomolecules and their metabolites encoded in our eukaryotic genome and supplemented by an even larger pool of prokaryotic genes and products. This symbiotic coexistence is presumed to have evolved to necessitate the sharing of biological and biochemical needs important for growth, body physiology, survival and reproduction. LÄS MER