Sökning: "genotype-based recall"

Hittade 2 avhandlingar innehållade orden genotype-based recall.

1. 1. Role of nuclear receptors in the regulation of human adipose tissue metabolism

   Författare :Prasad G. Kamble; Jan W Eriksson; Ingrid Dahlman; Uppsala universitet; []
   Nyckelord :human adipose tissue; nuclear receptors; glucocorticoids; estrogen; PPARγ; lipocalin 2; glucose uptake; lipolysis; adipogenesis; genotype-based recall;

   Sammanfattning : Nuclear receptors modulate expression of genes involved in adipose tissue (AT) metabolism. Their improved understanding may provide new treatment options for metabolic disorders such as obesity, insulin resistance (IR) and type 2 diabetes (T2D). LÄS MER

3. 2. Enhancing prediction and causal inference in metabolic dyshomeostasis

   Författare :Naeimeh Atabaki Pasdar; Genetisk och molekylär epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : This thesis is focused on two globally prevalent diseases: i) non-alcoholic fatty liver disease (NAFLD) and ii) type 2 diabetes (T2D), with an overall aim of improving prediction and causal inference in the context of these conditions. Our projects were mainly conducted using IMI DIRECT and UK Biobank datasets including multi-omics data, extensive environmental exposures, and biological intermediates. LÄS MER