Sökning: "lipocalin 2"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden lipocalin 2.

1. 1. Structure and distribution of alpha-1-microglobulin proteins

   Författare :Tord Berggård; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteins; lysine; chromophore; placenta; immunohistochemistry; albumin; prothrombin; plasma; bikunin; lipocalin; alpha-1-microglobulin; protein HC; enzymology; Proteiner; enzymologi;

   Sammanfattning : This thesis describes studies of the structure and tissue distribution of alpha-1-microglobulin (a1-m), a member of the lipocalin protein superfamily with immunosuppressive properies. It was shown that a1-m appears in human plasma in five major forms. LÄS MER

3. 2. Alpha-1-microglobulin, heme-binding protein, reductase and antioxidant

   Författare :Maria Allhorn; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reduction; inflammation; chronic ulcers; collagen; low density lipoproteins; Medicin människa och djur ; Medicine human and vertebrates ; antioxidation; heme; hemoglobin; alpha-1-microglobulin; lipocalin;

   Sammanfattning : This thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa plasma and tissue protein that is evolutionarily well-conserved and belongs to the lipocalin superfamily. The lipocalins are polypeptides of 160-190-amino acids that are folded into an 8-stranded beta-barrel forming a pocket with a hydrophobic interior. LÄS MER

4. 3. Role of nuclear receptors in the regulation of human adipose tissue metabolism

   Författare :Prasad G. Kamble; Jan W Eriksson; Ingrid Dahlman; Uppsala universitet; []
   Nyckelord :human adipose tissue; nuclear receptors; glucocorticoids; estrogen; PPARγ; lipocalin 2; glucose uptake; lipolysis; adipogenesis; genotype-based recall;

   Sammanfattning : Nuclear receptors modulate expression of genes involved in adipose tissue (AT) metabolism. Their improved understanding may provide new treatment options for metabolic disorders such as obesity, insulin resistance (IR) and type 2 diabetes (T2D). LÄS MER

5. 4. The microbiome, PPARγ and AhR in the inflammation-metabolism interface within the gastrointestinal tract

   Författare :Agata Korecka; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The mammalian body is a mosaic of different organisms - a holobiont, which contains all the biomolecules and their metabolites encoded in our eukaryotic genome and supplemented by an even larger pool of prokaryotic genes and products. This symbiotic coexistence is presumed to have evolved to necessitate the sharing of biological and biochemical needs important for growth, body physiology, survival and reproduction. LÄS MER

7. 5. The secretome of brown adipose tissue

   Författare :Ida R. Hansen; Jan Nedergaard; Francesco Villarroya; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fysiologi; Physiology;

   Sammanfattning : Brown adipose tissue has long been known for its heat-producing capacity, but less is known about its possible effects as a secretory organ. This thesis summarizes information about presently known factors secreted from brown adipose tissue and about their actions. We were able to add factors to the list by the use of a signal-sequence trap method. LÄS MER