Sökning: "nuclear hormone receptor"

Visar resultat 11 - 15 av 80 avhandlingar innehållade orden nuclear hormone receptor.

  1. 11. Growth hormone regulation of LFABP and PPARa. Genes involved in hepatic lipid metabolism

    Författare :Linda Carlsson; Göteborgs universitet; []
    Nyckelord :Growth hormone; fatty acids; rat; hepatocyte; LFABP; C EBPa; PPARa;

    Sammanfattning : Growth hormone (GH) is known to have several important effects in the control of metabolism. The aim of these studies was to investigate how GH regulates genes involved in fatty acid transport and metabolism in the liver and the interaction between GH and fatty acids in this regulation. LÄS MER

  3. 12. The role of PPARalpha and growth hormone in hepatic lipid metaboism and atherosclerosis

    Författare :Anna Ljungberg; Göteborgs universitet; []
    Nyckelord :growth hormone; PPARalpha; atherosclerosis; lipid metabolism; fatty acids; apoB; ; ADRP; triglycerides; PGC-1; liver;

    Sammanfattning : Dyslipidemia mainly results from oversecretion of apoB-containing lipoproteins from theliver and is one of the most important risk factors for the development of atherosclerosis.Growth hormone (GH) plays a key role in the regulation of lipoprotein metabolism and thus,disturbances in GH secretion are associated with dyslipidemia and cardiovascular disease. LÄS MER

  4. 13. Therapy of neuroendocrine tumors with 177Lu-octreotate - Human tumor cell types and models and optimization of treatment : Terapi av neuroendokrina tumörer med 177Lu-octreotate

    Författare :Johanna Dalmo; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; somatostatin; radionuclide therapy; receptor up-regulation; RBP; nephrotoxicity;

    Sammanfattning : Neuroendocrine (NE) tumors (NET) have often metastasized at the time of diagnose, which makes it hard to cure patients with NET. Radiolabeled hormone analogues (especially somatostatin analogues, SS) can be used for diagnostics (e.g. 111In-octreotide) and therapy (e. LÄS MER

  5. 14. Pituitary Tumors - Epidemiology and the Diagnostic Value of 68Ga-DOTATOC PET

    Författare :Axel Tjörnstrand; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; Pituitary neuroendocrine tumor; pituitary tumor; somatostatin receptor imaging; gallium68; 68Ga; SSTR; SSTR-PET;

    Sammanfattning : Pituitary neuroendocrine tumors (PitNETs) are considered common in the general population. However benign in most cases, these tumors can evoke dramatic morbidity in patients with aggressive tumor growth and/or excess hormone secretion. LÄS MER

  7. 15. Regulation of STAT5 activity by growth hormone

    Författare :Tony J Pircher; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :growth hormone janus kinase; STAT5; MAP kinase; phosphatase;

    Sammanfattning : The growth hormone (GH) receptor is a member of the cytokine receptor superfamily. This receptor family has certain common characteristics, among them the absence of a canonical tyrosine kinase consensus sequence and the association with the Janus family of cytosolic tyrosine kinases (JAK). The predominant JAK utilized by the GH receptor is JAK2. LÄS MER