Sökning: "nociceptin"

Visar resultat 11 - 14 av 14 avhandlingar innehållade ordet nociceptin.

1. 11. Opioid and non-opioid activities of the dynorphins

   Författare :Zoya Marinova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN). Dynorphins regulate pain processing and memory acquisition and modulate reward induced by intake of addictive substances. LÄS MER

3. 12. Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

   Författare :Igor Bazov; Georgy Bakalkin; Catharina Lavebratt; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuropeptides; dynorphin; human brain; alcohol dependence; epigenetics; gene transcription;

   Sammanfattning : Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. LÄS MER

4. 13. In vitro and postmortem studies of the brain opioid system : association to opiate dependence

   Författare :Parisa Zarnegar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Opioid system; brain; gene expression; amygdala; hippocampus; opiate dependence;

   Sammanfattning : Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. LÄS MER

5. 14. Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders

   Författare :Abdul Maruf Asif Aziz; Annika Thorsell; David Engblom; Elizabeth Jerlhag; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. LÄS MER