Sökning: "Annika Thorsell"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Annika Thorsell.

  1. 1. Central neuropeptide Y (NPH) expression and function : role in stress, experimental anxiety, and cognition

    Författare :Annika Thorsell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neuropeptide Y; stress; experimental anxiety; cognition; lipid-mediated gene transfer; transgenic animals; rat;

    Sammanfattning : Neuropeptide Y (NPY), a 36 amino acid peptide abundantly expressed throughout the mammalian nervous system, has been implicated in experimental anxiety and stress related responses, feeding, and learning and memory. These functions are mediated via different receptor subtype populations (Y1-Y6), all belonging to the G-protein coupled receptor superfamily. LÄS MER

  3. 2. Mass spectrometry based proteomic strategies applied in the study of central nervous system derived cells

    Författare :Annika Thorsell; Göteborgs universitet; []
    Nyckelord :proteomics; mass spectrometry; protein identification; protein quantitation; fractionation;

    Sammanfattning : This thesis focuses on evaluation, improvement and development of mass spectrometry based proteomic strategies for identification and quantitation of proteins. Development of such strategies is important to achieve a better understanding of regulatory mechanisms of individual cell types, both during normal development and during the onset and progression of diseases. LÄS MER

  4. 3. Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders

    Författare :Abdul Maruf Asif Aziz; Annika Thorsell; David Engblom; Elizabeth Jerlhag; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. LÄS MER

  5. 4. Overlapping Neural Substrates of Alcohol- and Anxiety-Related Behavior in the Rat

    Författare :Riccardo Barchiesi; Estelle Barbier; Markus Heilig; Annika Thorsell; Andrew Holmes; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcohol use disorder; Anxiety disorder; Behavior; Rat; Prelimbic cortex; Amygdala; Basolateral amygdala; Stress; Epigenetics; Syt1; Prdm2; Avp; Conditioned fear; Social defeat stress; Witness stress; Susceptibility; Resilience;

    Sammanfattning : Alcohol use is a leading cause of death and disease worldwide. A large part of this disease burden is associated with alcohol use disorder (AUD), a diagnostic category characterized by excessive use in spite of negative consequences ("compulsive use"), a loss of control over intake, and choice of alcohol over natural rewards. LÄS MER

  7. 5. Inflammatory Signaling Across the Blood-Brain Barrier and the Generation of Fever

    Författare :Anna Eskilsson; David Engblom; Annika Thorsell; Göran Engberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Fever is a cardinal sign of inflammation and is evolutionary conserved. Fever is known to be beneficial during acute inflammation, but over time and if very high it can be detrimental. LÄS MER