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Visar resultat 1 - 5 av 16 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Behavior and cytogenesis following irradiation or isoflurane exposure to the developing brain

   Författare :Niklas Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiotherapy; isoflurane; anesthesia; hippocampus; neurogenesis; memory; learning; intellicage; dentate gyrus; trace fear conditioning; open field; object recognition;

   Sammanfattning : In this thesis, the effects of an anesthetic agent, isoflurane, on the young brain and resulting behavioral effects were investigated. Anesthesia is commonly used in young children during surgery or other procedures associated with pain or discomfort. LÄS MER

3. 2. Spatial and temporal regulation of neural stem cells in the developing brain by PRDM16

   Författare :Li He; Qi Dai; Christos Samakovlis; Simon Hippenmeyer; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain development; Neural stem cell; PRDM16; BMP signaling; Choroid plexus; Cortical neurogenesis; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : The mammalian brain comprises a large number and diversity of neurons and non-neural cells. Most of these cell types derive from a single sheet of neuroepithelium (NE) that contains a limited pool of neural stem cells (NSCs).  NSCs in the developing brain are under complex regulation to achieve maximum daughter cell type diversity. LÄS MER

4. 3. Inflammation and Cell Profileration Following Perinatal Brain Injury

   Författare :Katarina Järlestedt; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia-ischemia; immature brain; reactive gliosis; complement system; C3a; fear conditioning; lipopolysaccharide; inflammation;

   Sammanfattning : Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) brain injury, (2) the role of complement derived peptide C3a in neonatal HI brain injury, (3) the effect of neonatal HI brain injury on fear learning and behaviour, (4) the effects of lipopolysaccharide (LPS) induced systemic inflammation on cell proliferation in the developing brain. LÄS MER

5. 4. Apoptosis and inflammation regulation after injury to the developing brain

   Författare :Wei Han; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The brain shows greater plasticity in early life than in maturity, which paradoxically renders the organ more vulnerable to hypoxia-ischemia (HI)- and cranial irradiation (IR)- induced damage. Apoptosis after a HI insult is more pronounced in the immature vs. LÄS MER

7. 5. The Regulatory Role of microRNAs in the Mouse and Human Brain

   Författare :Rebecca Petri; Molekylär neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microRNA; Argonaute; AGO-RIP; let-7; miR-125; adult neurogenesis; olfactory bulb; autophagy; transposable elements; LINE-2; Huntington’s disease;

   Sammanfattning : microRNAs (miRNAs) are 20-24 nucleotides small, single-stranded, non-coding RNAs. They associate with Argonaute (AGO) proteins and exert their function by inhibition or degradation of messenger RNAs. LÄS MER