Sökning: "mitochondrial ROS"

Visar resultat 1 - 5 av 66 avhandlingar innehållade orden mitochondrial ROS.

1. 1. Integrin Signaling in Cell Adhesion and Mechanotransduction : Regulation of PI3K, AKT, and ROS

   Författare :Kathrin Stephanie Zeller; Staffan Johansson; Kristofer Rubin; John Couchman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; integrin; ROS; PI3K; AKT; mechanosignaling; actin polymerization; spreading;

   Sammanfattning : Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. LÄS MER

3. 2. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

   Författare :Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. LÄS MER

4. 3. Significance of mitochondrial ultrastructure for bioenergetics

   Författare :Alexandra Toth; Martin Ott; Vladimir Gogvadze; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioenergetics; mitochondrial ultrastructure; respiratory chain; Saccharomyces cereviciae; ATP synthase; apoptosis; cytochrome c; supercomplexes; Biochemistry; biokemi;

   Sammanfattning : Mitochondria are the site where most of the energy from food is converted into adenosine triphosphate (ATP). This process is taking place at the inner membrane (IM) of mitochondria, and is called oxidative phosphorylation, and results in the establishment of a proton motive force (pmf). LÄS MER

5. 4. Mitochondrial dysfunction in neurodegeneration

   Författare :Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

   Sammanfattning : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). LÄS MER

7. 5. Oxygen sensing in Caenorhabditis elegans

   Författare :Lina Zhao; Changchun Chen; Simon Tuck; Helena Edlund; Marc Pilon; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; C. elegans; acute hypoxia; G-protein; mitochondrial ROS; neuropeptide; GPCR;

   Sammanfattning : Sufficient supply of oxygen (O2) to tissue is essential for survival of aerobicanimals. In mammals, there are constant homeostatic regulation mechanisms that act on different time scales to maintain optimal O2 delivery to tissues. The ability to detect and respond to acute oxygen shortages is indispensable to aerobic life. LÄS MER