Sökning: "Helena Edlund"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Helena Edlund.

1. 1. Analysis of Metabolites in Complex Biological Samples Using LC/MS and Multivariate Data Analysis : Metabolic Fingerprinting and Detection of Biomarkers

   Författare :Helena Idborg; Sven Jacobsson; Per-Olof Edlund; Jonas Bergquist; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Metabonomics; Metabolic Fingerprinting; Drug Metabolism; Biomarkers; Human Plasma; Rat Urine; LC MS; ZIC-HILIC; UPLC; UHPLC; ToF; Curve Resolution; Peak Detection; Pattern Recognition; Classification; PCA; PLS; PARAFAC; N-PLS; Data Fusion; Hierarchical Modeling; Batch modeling; Data Concatenation; Breast Cancer; Phospholipidosis; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : To facilitate early diagnosis of diseases and elucidation of the processes involved in their development and progression, various specific compounds or ‘biomarkers’ are often monitored. The first step is to decide which compounds to analyze. LÄS MER

3. 2. Diabetes in 3D : β-cell mass assessments in disease models & evaluation of SPECT based imaging

   Författare :Saba Parween; Ulf Ahlgren; Helena Edlund; Eckhard Lammert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Optical projection tomography; Diabetes; β-cell mass; disease etiology; 3D imaging; radiotracers; Single photon emission computed tomography; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

   Sammanfattning : Diabetes is a rapidly growing disease with 415 million affected adults worldwide. The pancreatic endocrine cells, most importantly the insulin producing β-cells, play an important role in regulating blood glucose homeostasis. LÄS MER

4. 3. The regulation of incorrect splicing of ISCU in hereditary myopathy with lactic acidosis

   Författare :Denise F. R. Rawcliffe; Monica Holmberg; Helena Edlund; Diana Baralle; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HML; ISCU; Splicing; SRSF3; PTBP1; RBM39; MBNL1; medicinsk genetik; Medical Genetics;

   Sammanfattning : Patients suffering from hereditary myopathy with lactic acidosis (HML) can be found in the northern Swedish counties of Ångermanland and Västerbotten. HML is a rare autosomal recessive disease where patients display a low tolerance to exercise at an early age. LÄS MER

5. 4. In vivo and in vitro approaches to induce beta cells from stem and progenitor cells

   Författare :Lars Selander; Helena Edlund; Yuval Dor; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreas; stem cell; progenitor; beta cell; in vitro; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; molecular medicine medical sciences ; molekylär medicin medicinska vetenskaper ;

   Sammanfattning : Diabetes or diabetes mellitus which is the correct medical term is a medical condition were the affected person lack the ability to regulate his or her blood glucose levels. This inability is directly due to the fact that the insulin producing cells, residing in the pancreas, can’t meet the body’s demand for insulin. LÄS MER

7. 5. Functional analysis of Ipf1/Pdx1, MFng and Id during pancreatic growth and differentiation

   Författare :Per Svensson; Helena Edlund; Henrik Semb; Umeå universitet; []
   Nyckelord :pancreas; proliferation; differentiation; signalling; expression; FgfR2IIIb; ErbB3; spondin1; MFng; Id; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

   Sammanfattning : The pancreas is an endodermally derived organ consisting of three major cell lineages. The endocrine cells, organised into the Islets of Langerhans, regulate blood glucose homeostasis by producing and secreting hormones such as glucagon and insulin into the bloodstream. LÄS MER