Sökning: "micro RNA"

Visar resultat 1 - 5 av 40 avhandlingar innehållade orden micro RNA.

  1. 1. Micro-RNA: The “Micro”-managers of cardiovascular diseases - Role of extracellular vesicles-mediated miRNAs in cardiovascular diseases

    Författare :Kreema James; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiology; molecular biology; extracelluar vesicles; Micro-RNA; Protein;

    Sammanfattning : Cardiovascular disease (CVD) is the leading cause of death globally, impacted by both extrinsic and intrinsic factors. The disease at the molecular level, however, is governed by inflammation and characterized by endothelial dysfunction. LÄS MER

  3. 2. Dissecting the role of micro-RNAs in diabetes

    Författare :Caroline Bolmeson; Create Health; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Sammanfattning : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. LÄS MER

  4. 3. Stromal components and micro-RNAs as biomarkers in pancreatic cancer

    Författare :Oskar Franklin; Malin Sund; Daniel Öhlund; Ola Billing; Marco Del Chiaro; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; stroma; basement membrane; tumour markers; type IV collagen; endostatin; osteopontin; tenascin c; hyaluronan; CD44; micro-RNA; kirurgi; Surgery;

    Sammanfattning : Background Pancreatic ductal adenocarcinoma (PDAC) patients have the poorest 5-year survival rates of all cancer forms. It is difficult to diagnose at early disease stages, tumour relapse after surgery is common, and current chemotherapies are ineffective. LÄS MER

  5. 4. The multi-faceted RNA molecule : Characterization and Function in the regulation of Gene Expression

    Författare :Mats Ensterö; Marie Öhman; Jørgen Kjems; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Computational Biology; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : In this thesis I have studied the RNA molecule and its function and characteristics in the regulation of gene expression. I have focused on two events that are important for the regulation of the transcriptome: Translational regulation through micro RNAs; and RNA editing through adenosine deaminations. LÄS MER

  7. 5. Prognostic markers and DNA methylation profiling in lymphoid malignancies

    Författare :Sujata Bhoi; Richard Rosenquist Brandell; H Denis Alexander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; CLL; MCL; prognostic markers; micro-RNA; methylation; stereotyped subsets;

    Sammanfattning : In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. LÄS MER