Sökning: "MCL"

Visar resultat 1 - 5 av 54 avhandlingar innehållade ordet MCL.

1. 1. Revision anterior cruciate ligament reconstruction - current evidence, predictors and outcome

   Författare :Eleonor Svantesson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anterior cruciate ligament; ACL; reconstruction; revision; medial collateral ligament; MCL; knee;

   Sammanfattning : Despite extensive research in the field of anterior cruciate ligament (ACL) reconstruction, primary ACL reconstruction failure and a high re-rupture rate remain a problem. Far too many patients experience a second devastating hit – the need to undergo a revision ACL reconstruction. LÄS MER

3. 2. Knee ligament injuries in male professional football players

   Författare :Matilda Lundblad; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; knee; ligament; MCL; LCL; ACL; PCL; professional football;

   Sammanfattning : ABSTRACT Knee ligament injuries are common in professional football and entail a significant time loss from football, but studies of knee ligament injuries other than anterior cruciate ligament (ACL) injuries are scarce. The aim of this thesis was prospectively to study the epidemiology and characteristics of medial collateral ligament (MCL), lateral collateral ligament (LCL) and posterior cruciate ligament (PCL) injuries in male professional football players with the main emphasis on MCL injuries. LÄS MER

4. 3. Prognostic markers and DNA methylation profiling in lymphoid malignancies

   Författare :Sujata Bhoi; Richard Rosenquist Brandell; H Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; CLL; MCL; prognostic markers; micro-RNA; methylation; stereotyped subsets;

   Sammanfattning : In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. LÄS MER

5. 4. Genetic studies of neuroblastoma with emphasis on the apoptotic pathway

   Författare :Frida Abel; Göteborgs universitet; []
   Nyckelord :child; cancer; neuroectodermal; neural crest; loss of heterozygosity; LOH; bcl-2; mcl-1; apaf-1; caspase-2; caspase-3; caspase-9; PIN; DLC-1; caspase-2;

   Sammanfattning : Aim: The objective of this thesis was to find genes and chromosomal regions involved in neuroblastoma (NB) tumor progression. NB is a childhood tumor of the sympathetic nervous system that generally occurs spontaneously. LÄS MER

7. 5. Molecular Investigations of high-risk Mantle Cell Lymphoma : Genetic factors and the impact of the microenvironment

   Författare :Joana de Matos Rodrigues; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; CPT1A; TP53; c-Myc; Immune microenvironment; Macrophages;

   Sammanfattning : Mantle cell lymphoma (MCL) is an aggressive disease, with variable clinical course and heterogenous molecular characteristics. In this thesis, which is based upon six original papers, we aimed to understand MCL deregulations, both at intrinsic and extrinsic levels, to identify companion biomarkers that would allow patient stratification. LÄS MER