Sökning: "metabolic flux analysis"

Visar resultat 16 - 20 av 40 avhandlingar innehållade orden metabolic flux analysis.

1. 16. Constraint-based modeling of metabolism - interpreting predictions of growth and ATP synthesis in human and yeast

   Författare :Avlant Nilsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; the Crabtree effect; enzyme-constraints; stunting; cellular economy; the Warburg effect; uncoupling; tumor; flux balance analysis; lactate threshold; metabolite depletion;

   Sammanfattning : Growth is the primary objective of the cell. Diseases arise when cells diverge from a healthy growth-pattern. An increased understanding of cellular growth may thus be translated into improved human health. The cell requires materials and free energy (in the form of ATP) in order to grow, metabolism supplies the cell with this. LÄS MER

3. 17. Computing abundance constraints in Saccharomyces cerevisiae’s metabolism

   Författare :Benjamín José Sánchez; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome-scale modeling; lipidomics; proteomics; flux balance analysis;

   Sammanfattning : The unicellular eukaryotic organism Saccharomyces cerevisiae (budding yeast) is routinely used for production of high-value chemical compounds in the biotechnology industry. To improve production yields, it is fundamental to understand cellular metabolism, i.e. all biochemical reactions that occur inside the cell. LÄS MER

4. 18. Mathematical Modelling of Cellular Ageing: a Multi-Scale Perspective

   Författare :Barbara Schnitzer; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; replicative ageing; healthy ageing; yeast; complex systems; multi-scale model; hybrid model; flux balance analysis; ordinary differential equations; Boolean modelling;

   Sammanfattning : In a growing and increasingly older population, we are progressively challenged by the impact of ageing on individuals and society. The UN declared the years 2021-2030 as the Decade of Healthy Ageing, highlighting the efforts to minimise the burden of ageing and age-related diseases. LÄS MER

5. 19. Hydrogen Production by Caldicellulosiruptor species: The Organism and the Metabolism

   Författare :Ahmad Zeidan; Teknisk mikrobiologi; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Extreme thermophile; Caldicellulosiruptor; Biohydrogen; Co-culture; Coexistence; Hydrogen tolerance; Genome-scale reconstruction; In silico; Flux balance analysis;

   Sammanfattning : Hydrogen holds a great promise as an efficient and clean future energy carrier due to its high energy density and lack of pollutant generation. Anaerobic degradation of organic substrates by heterotrophic microorganisms enables the production of hydrogen from a wide spectrum of agricultural feedstock and waste products. LÄS MER

7. 20. Metabolomics and flux analysis by mass spectrometry : Investigations of factors associated with insulin secretion and prostate cancer risk

   Författare :Johnny Östman; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Two of the most common diseases associated with the Western lifestyle are type 2 diabetes (T2D) and prostate cancer (PCa). This is in large part due to decreased physical activity, surplus of dietary energy, and an ageing population. LÄS MER