Sökning: "Genome-scale reconstruction"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Genome-scale reconstruction.

1. 1. On metabolic networks and multi-omics integration

   Författare :Rasmus Ågren; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

   Sammanfattning : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. LÄS MER

3. 2. Reconstruction of Biological Networks for Integrative Analysis

   Författare :Tobias Österlund; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transcriptional regulation; : Biological networks; integrative analysis; protein secretion; genome-scale metabolic model;

   Sammanfattning : Biological systems can be very complex and consist of several thousand components that interact with each other in the cell. One of the goals of systems biology is to study biological systems from a systemic viewpoint in order to get an increased understanding of the behavior of the cell. LÄS MER

4. 3. Hydrogen Production by Caldicellulosiruptor species: The Organism and the Metabolism

   Författare :Ahmad Zeidan; Teknisk mikrobiologi; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Extreme thermophile; Caldicellulosiruptor; Biohydrogen; Co-culture; Coexistence; Hydrogen tolerance; Genome-scale reconstruction; In silico; Flux balance analysis;

   Sammanfattning : Hydrogen holds a great promise as an efficient and clean future energy carrier due to its high energy density and lack of pollutant generation. Anaerobic degradation of organic substrates by heterotrophic microorganisms enables the production of hydrogen from a wide spectrum of agricultural feedstock and waste products. LÄS MER

5. 4. A systems biology understanding of protein constraints in the metabolism of budding yeasts

   Författare :Iván Domenzain Del Castillo Cerecer; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gene regulation; omics analysis; enzyme capacity; metabolism; systems biology; stress adaptation; genome-scale modeling; metabolic engineering;

   Sammanfattning : Fermentation technologies, such as bread making and production of alcoholic beverages, have been crucial for development of humanity throughout history. Saccharomyces cerevisiae provides a natural platform for this, due to its capability to transform sugars into ethanol. LÄS MER

7. 5. An insight towards food-related microbial sets through metabolic modelling and functional analysis

   Författare :Simonas Marcisauskas; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RAVEN; gut; systems biology; comparative genomics; Kluyveromyces marxianus; bile acids; genome-scale metabolic model; next-generation sequencing; transcriptomics; thermotolerance;

   Sammanfattning : The dietary food digestion depends on the human gastrointestinal tract, where host cells and gut microbes mutually interact. This interplay may also mediate host metabolism, as shown by microbial-derived secondary bile acids, needed for receptor signalling. Microbes are also crucial in the production of fermented foods, such as wine and dairy. LÄS MER