Sökning: "liver disease alcohol"

Visar resultat 16 - 20 av 31 avhandlingar innehållade orden liver disease alcohol.

  1. 16. Role of membrane associated molecules in liver fibrosis

    Författare :Peter Rosenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adhesion molecules; liver fibrosis; cholestasis; R-cadherin; N-CAM; EBP50; CFTR; cystic fibrosis; methotrexate; diabetes; over-weight; alcohol;

    Sammanfattning : The aim of the study was to evaluate the role of membrane associated proteins in tissue formation and remodeling, in normal embryogenesis and in liver disease. Molecules associated with cellular membranes provide a fundamental basis for cellular interactions during development, homeostasis and disease. LÄS MER

  3. 17. Alpha-1-antitrypsin deficiency (PiZ): Clinical studies with special regard to hepatic and vasculitic disorders

    Författare :Abdul-Nasser Elzouki; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastro-enterology; systemic vasculitis; small-vessel vasculitis; serpins; genetic hemochromatosis; chronic hepatitis C; chronic liver disease; Alpha-1-antitrypsin deficiency; alpha-1-antichymotrypsin deficiency; Gastroenterologi; Urology; nephrology; Urologi; nefrologi;

    Sammanfattning : Homozygous alpha-1-antitrypsin (AAT)deficiency (PiZZ) is known to predispose to emphysema and chronic liver disease (CLD). The overall aim of the studies upon which this thesis is based was to investigate extra-pulmonary disease manifestations of AAT deficiency with special reference to hepatic and vasculitic disorders. LÄS MER

  4. 18. Cardiovascular disease risk among people living with HIV in South Central Uganda

    Författare :Rocio Enriquez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: With the introduction of effective antiretroviral therapy (ART), the clinical management needs of people living with HIV are rapidly shifting from AIDS-related opportunistic infections to age-related co-morbidities. Research from high-income countries has demonstrated that people living with HIV are at an increased risk for developing cardiovascular disease (CVD) due to a combination of increased traditional CVD risk factors, HIV infection, and ART use. LÄS MER

  5. 19. Experimental and clinical studies on liver regeneration and hepatocellular carcinoma : roles of redox proteins, iron homeostasis and multikinase inhibition

    Författare :Annelie Mollbrink; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Compensatory liver regeneration is triggered by chronic liver injury or surgery and is crucial to maintain tissue homeostasis. The underlying mechanisms which include a whole battery of complex signaling events have been thoroughly studied for decades. LÄS MER

  7. 20. The importance of Cyclophilins and Mps1 in cancer

    Författare :Sonia Simon Serrano; Klinisk neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclophilins; liver; fibrosis; HCC; cell cycle; Mps1 and mitosis;

    Sammanfattning : Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. LÄS MER