Sökning: "intracellular free Ca2"

Visar resultat 11 - 15 av 40 avhandlingar innehållade orden intracellular free Ca2.

  1. 11. Ion channels and electrical activity in vascular smooth muscle: Effects of calcium store depletion, cholesterol and cholesterol-lowering drugs

    Författare :Andreas Bergdahl; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Physiology; statins; endothelin; cholesterol; caveolae; smooth muscle; TRP; Ca2 channels; SOC;

    Sammanfattning : Smooth muscle cells (SMCs) in the vessel wall contract to regulate blood flow and pressure, a function essential for normal circulation through tissues. On the other hand, migration and proliferation of SMCs are important factors in vascular disease, such as atherosclerosis and restenosis following surgical dilatation. LÄS MER

  3. 12. Regulation of Attachment and Early Intracellular Development of Chlamydia trachomatis in Eucaryotic Cells

    Författare :Meytham Majeed; Martin Lindberg; Östergötlands Läns Landsting; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The obligate intracellular bacterium, Chlamydia trachomatis , a common human pathogen, causing different diseases in both males and females, as well as in infants born to infected mothers. Occasionally, these diseases involve serious complications, such as blindness and infertility. C. LÄS MER

  4. 13. Metabolic signals in the regulation of insulin release

    Författare :Jude T Deeney; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :insulin-secreting cells; glucose metabolism; ATP ADP ratio; cytoplasmic free Ca2 concentration; long-chain acyl-CoA; protein kinase C; insulin secretion; serotonin release; permeabilized cells; intracellular Ca2 handling; exocytosis;

    Sammanfattning : In the present thesis, an attempt was made to elucidate the role of some of the glucose-induced intracellular metabolic effector signals in insulin secretion and to develop new applications that will enable further investigations of oscillatory signalling and secretion from pancreatic ß-cells. The sequence of early metabolic and ionic events was examined in clonal pancreatic insulin secreting cells (HIT) in response to glucose stimulation. LÄS MER

  5. 14. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

  7. 15. Mechanisms regulating ion transport in the secretory epithelia of the inner ear : an experimental study

    Författare :Charlotte Ågrup; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :inner ear; stria vascularis; endolymphatic sac; endolymph; Na ; K -ATPase; plasma membrane-bound Ca2 -ATPase; fura-2 method; immunohistochemistry; immunoblotting; guinea pig;

    Sammanfattning : The apical portions of the cells in the sensory end organs for audition and equilibrium border a fluid called endolymph. Endolymph is the only extracellular fluid in the body which is characterized by an intracellular-like ion composition. LÄS MER