Sökning: "ATP ADP ratio"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden ATP ADP ratio.

  1. 1. Astrocyte metabolism following focal cerebral ischemia

    Författare :Anna E Thoren; Göteborgs universitet; []
    Nyckelord :Astrocyte; metabolism; focal cerebral ischemia; reperfusion; infarct; [1-14C]acetate; [U-14C]glucose; glutamine; glutamate; ATP; ADP; lactate; MCT4; immunogold cytochemistry;

    Sammanfattning : Stroke is one of the leading causes of disability and death. Most often, stroke results from blockage of an artery in the brain leading to tissue infarction within the perfusion territory of the affected vessel. LÄS MER

  3. 2. Mitochondrial function in human skeletal muscle: with special reference to exercise and training

    Författare :Michail Tonkonogi; Högskolan Dalarna; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aerobic metabolism; oxidative phosphorylation; mitochondria; oxygen utilisation; citrate synthase; ADP sensitivity; ATP; muscle fibres; hydrogen ions; lactate; free radicals; proton leak; uncoupling; exercise; aerobic metabolism; oxidative phosphorylation; mitochondria; oxygen utilisation; citrate synthase; ADP sensitivity; ATP; muscle fibres; hydrogen ions; lactate; free radicals; proton leak; uncoupling; exercise;

    Sammanfattning : The overall objective of this thesis was to study the adaptation of oxidative function in human skeletal muscle to acute exercise of different modes, intensities and durations, and to endurance training. The effects of endurance training on mitochondrial function were evaluated in cross-sectional and longitudinal studies by measurements of mitochondrial oxygen consumption in isolated mitochondria and permeabilised muscle fibres and measurements of mitochondrial ATP production rate in isolated mitochondria. LÄS MER

  4. 3. Regulation of Phospholipase C and Plasma Membrane Phosphatidylinositol 4,5-bisphosphate in Insulin-Secreting Cells

    Författare :Sophia Thore; Anders Tengholm; Erik Gylfe; Peter Jones; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; PLC; PIP2; insulin-secreting cell; Ca2 ; evanescent wave microscopy; phosphoinositide kinase; ATP ADP ratio; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is an important signaling molecule as substrate for the phospholipase C (PLC)-catalyzed formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol, and by directly regulating e.g. ion-channels, the cytoskeleton and vesicle trafficking in various types of cells. LÄS MER

  5. 4. Metabolic signals and the ATP-sensitive potassium channel in the pancreatic beta-cell

    Författare :Robert Bränström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP-regulated K channel; pancreatic [beta]-cell oscillations; [alpha]-ketoisocaproate; long chain acyl-CoA esters; Kir6.2 SUR1 structure-function.;

    Sammanfattning : ATP-sensitive K+ (KATP) channels are widely distributed in a variety of tissues and cell types. KATP channels are comprised of two subunits, a pore forming subunit (Kir6.x) and a regulatory sulfonylurea receptor (SURx). Both subunits are required for fully functional channels. LÄS MER

  7. 5. Metabolic signals in the regulation of insulin release

    Författare :Jude T Deeney; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :insulin-secreting cells; glucose metabolism; ATP ADP ratio; cytoplasmic free Ca2 concentration; long-chain acyl-CoA; protein kinase C; insulin secretion; serotonin release; permeabilized cells; intracellular Ca2 handling; exocytosis;

    Sammanfattning : In the present thesis, an attempt was made to elucidate the role of some of the glucose-induced intracellular metabolic effector signals in insulin secretion and to develop new applications that will enable further investigations of oscillatory signalling and secretion from pancreatic ß-cells. The sequence of early metabolic and ionic events was examined in clonal pancreatic insulin secreting cells (HIT) in response to glucose stimulation. LÄS MER