Sökning: "cytoplasmic free Ca2 concentration"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden cytoplasmic free Ca2 concentration.

  1. 1. Temporal monitoring of intracellular Ca2+ signaling and origins of Ca2+ oscillations

    Författare :Dominic-Luc Webb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis examined parameters influencing stimulated cytoplasmic free Ca2+ concentration ([Ca2+]i) oscillations in hepatocytes and pancreatic beta-cells. Hepatic glucose output is regulated in part by hormones such as vasopressin that act through [Ca 2+]i oscillations. LÄS MER

  3. 2. Effects of imidazoline compounds on intracellular CA2+ and apoptosis

    Författare :Ioulia Appelskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :imidazolines; imidazoline site; sulfonylurea; glucose; interleukin-1beta; insulin secretion; glucagon; somatostatin; pancreatic islets; pancreatic P-cells; HIT-T15 cells; apoptosis; cytoplasmic free Ca2 concentration;

    Sammanfattning : Cytoplasmic free Ca2+ concentration ([Ca2+]i) plays a pivotal role in the regulation of insulin release from the pancreatic beta-cell. [Ca2+]i is also important in the control of apoptosis. LÄS MER

  4. 3. Studies on molecular mechanisms in calcium signaling and cellular energy consumption

    Författare :Kalaiselvan Krishnan; Hjalmar Brismar; Anders Tengholm; KTH; []
    Nyckelord :ca2 signaling; ATP; PercevalHR; NKA; diabetes; Angiotensin; Biological Physics; Biologisk fysik;

    Sammanfattning : Ion signaling plays fundamental role in cell survival. Na+ and Ca2+ are critical players in ion signaling. Cells spend the major amount of energy to maintain and regulate Na+ and Ca2+ gradients across the cell membrane. Any disruption in cellular energy consumption by plasma membrane ATPases affects ion signaling and vice versa. LÄS MER

  5. 4. Metabolic signals in the regulation of insulin release

    Författare :Jude T Deeney; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :insulin-secreting cells; glucose metabolism; ATP ADP ratio; cytoplasmic free Ca2 concentration; long-chain acyl-CoA; protein kinase C; insulin secretion; serotonin release; permeabilized cells; intracellular Ca2 handling; exocytosis;

    Sammanfattning : In the present thesis, an attempt was made to elucidate the role of some of the glucose-induced intracellular metabolic effector signals in insulin secretion and to develop new applications that will enable further investigations of oscillatory signalling and secretion from pancreatic ß-cells. The sequence of early metabolic and ionic events was examined in clonal pancreatic insulin secreting cells (HIT) in response to glucose stimulation. LÄS MER

  7. 5. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER