Sökning: "inter-individual variation"

Visar resultat 16 - 20 av 71 avhandlingar innehållade orden inter-individual variation.

  1. 16. Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation

    Författare :Ibrahim El-Serafi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens given prior to HSCT. LÄS MER

  3. 17. Biological Rhythms of Pancreatic Secretion in Young Pigs with empahasis to the time around weaning

    Författare :Mary-Jane Sebabatso Thaela; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Volume; Ultradian; Protein; Pancreas; Pig; IRCT; Insulin; Infradian; Glucose; Circadian; Chymotrypsin; Biologic week and Half-week; Chronome; Animal physiology; Djurfysiologi;

    Sammanfattning : When the time structure (chronome) of pancreatic secretion was studied after weaning in 5-week-old pigs, the zero-amplitude (no-rhythm) assumption was rejected for the about-weekly (circaseptan, CS) and about-half-weekly (circasemiseptan, CSS) chronome components. When the data were assessed individually on a day-to-day basis, a 24-hour component was suggested (P. LÄS MER

  4. 18. Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models

    Författare :Carl-Johan Rubin; Andreas Kindmark; Östen Ljunggren; Leif Andersson; David Burt; Uppsala universitet; []
    Nyckelord :Molecular medicine; QTL; Bone; Osteoporosis; Gene expression; Microarray; Domestication; Molekylärmedicin;

    Sammanfattning : Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements. LÄS MER

  5. 19. Lead in blood. ICP-MS studies of lead in plasma, blood and erythrocyte proteins

    Författare :Ingvar A Bergdahl; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; distribution; plasma; blood; erythrocytes; lead-binding prtoeins; delta-aminlevulinic acid dehydratase; inductively coupled plasma mass spectrometry; ALAD; arbetsmiljömedicin; Occupational health; industrial medicine; Lead; toxicity; ICP-MS; Yrkesmedicin;

    Sammanfattning : An inductively coupled plasma mass spectrometry (ICP-MS) method for the determination of lead in blood plasma has been developed. The detection limit was below 0.1 microgram/liter, and the precision 5%. There was no significant difference between levels in plasma and serum. LÄS MER

  7. 20. Clinical Pharmacogenetics of Olanzapine : with Focus on FMO Gene Polymorphisms

    Författare :Mao Mao Söderberg; Marja-Liisa Dahl; Maria Gabriella Scordo; Inger Johansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; olanzapine; pharmacogenetics; drug metabolism; schizophrenia; therapeutic drug monitoring; FMO1; FMO3; CYP1A2; UGT1A4; Clinical Pharmacology; Klinisk farmakologi;

    Sammanfattning : Pharmacogenetics is the study of variability in drug response attributed to genetic variation. Olanzapine (OLA) is a widely used antipsychotic drug for schizophrenia treatment. The pharmacokinetics of OLA display large inter-individual variation leading to multiple-fold differences in drug exposure between patients at a given dose. LÄS MER