Sökning: "inhibition"

Visar resultat 26 - 30 av 2341 avhandlingar innehållade ordet inhibition.

1. 26. Micro-galvanic effects and corrosion inhibition of copper-zinc alloys

   Författare :Mattias Forslund; Jinshan Pan; Christofer Leygraf; Per Claesson; Jin Ying; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Copper; zinc; brass; octadecanethiol; IR Spectroscopy; AFM; atmospheric corrosion; aqueous corrosion; corrosion inhibition; Koppar; zink; mässing; oktadekantiol; IR-reflektions absorptionsspektroskopi; AFM; atmosfärisk korrosion; vattenaktig korrosion; korrosionsinhibering.; Chemical Engineering; Kemiteknik; Kemi; Chemistry;

   Sammanfattning :    With the advancement and accessibility of local probing techniques that can operate at the submicron scale it has become possible to analyse the local corrosion properties of industrially important metallic materials and relate these properties to microstructure characteristics of the same materials. In this doctoral study the focus has been on copper-zinc samples, both as industrial brass alloys and as micro-patterned copper-zinc samples. LÄS MER

3. 27. Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery

   Författare :Maria T. Lindgren; Helena Danielson; Jozsef Tözser; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; kinetics; biosensors; ADME; drug discovery; SPR; resistance; inhibition; copper; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : A variety of HIV-1 protease inhibitors and their interactions with the enzyme have been characterized in order to identify novel and improved drugs against AIDS. The investigated inhibitors were represented by clinical and non-clinical inhibitors, active site and allosteric inhibitors, transition-state analogues and metal-ions. LÄS MER

4. 28. The Effect of Steroid Hormones in the Female Brain During Different Reproductive States

   Författare :Elin Bannbers; Inger Sundström-Poromaa; Johan Wikström; Kristiina Kask; Eriksson Elias; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Premenstrual dysphoric disorder; Postpartum; Estradiol; Progesterone; Menstrual cycle; Functional magnetic resonance imaging; Response inhibition; Prepulse inhibition; Startle response; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Women are twice as likely as men to suffer from depression and anxiety disorders and have an increased risk of onset during periods associated with hormonal changes, such as the postpartum period and the menopausal transition. Furthermore, some women seem more sensitive to normal hormone fluctuations across the menstrual cycle, since approximately 3-5% suffers from premenstrual dysphoric disorder (PMDD). LÄS MER

5. 29. The immunomodulatory properties of C-Med 100 an extract of the plant Uncaria tomentosa

   Författare :Christina Silver; Diabetes - immunovirologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; survival; proliferation; inhibition; NF-kB; Uncaria tomentosa; quinic acid;

   Sammanfattning : Extracts from the bark of the vine Uncaria tomentosa have anti-inflammatory, antiviral, antimutagenic and antioxidant effects. In this study, we evaluate the effects of an Uncaria tomentosa extract, denoted C-Med 100, on the cellular level of the immune system both in vivo and in vitro. LÄS MER

7. 30. Kinetic studies of NS3 and NS5B from Hepatitis C virus : Implications and applications for drug discovery

   Författare :Göran Dahl; Helena Danielson; Raffaele De Francesco; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; NS3; NS5B; enzyme kinetics; inhibition; resistance; drug; Biochemistry; Biokemi; Biokemi; Biochemistry;

   Sammanfattning : The aim of these studies was to increase our understanding of the non-structural proteins 3 and 5B (NS3 and NS5B) from the hepatitis C virus (HCV), and thereby contribute to the development of new and better drugs against HCV.By studying NS3 with substitutions identified to be associated with resistance to NS3 inhibitors in clinical trials (R155Q, A156T and D168V) it was found that not all inhibitors were affected, indicating that cross-resistance can be avoided. LÄS MER