Sökning: "neurotransmitter imaging"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden neurotransmitter imaging.

  1. 1. Imaging Anxiety : Neurochemistry in Anxiety Disorders Assessed by Positron Emission Tomography

    Författare :Andreas Frick; Mats Fredrikson; Tomas Furmark; David J Nutt; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Fear; Brain; Serotonin; Neurokinin; Substance P; Psychology; Psykologi;

    Sammanfattning : Anxiety disorders, including social anxiety disorder (SAD) and posttraumatic stress disorder (PTSD) are common and disabling conditions. Largely based on animal and pharmacological studies, both the serotonergic and substance P/neurokinin-1 (SP/NK1) systems have been implicated in their underlying pathology. LÄS MER

  2. 2. Neurotransmitter Imaging of the Human Brain : Detecting γ-Aminobutyric Acid (GABA) Using Magnetic Resonance Spectroscopy

    Författare :Sofie Tapper; Peter Lundberg; Anders Tisell; Peter Zsigmond; Richard Edden; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Introduction: In this thesis, MEGA-edited Magnetic Resonance Spectroscopy (MRS) has been used for the purpose of non-invasive detection of !- aminobutyric acid (GABA) within the brain. GABA is the main inhibitory neurotransmitter in the human central nervous system, and glutamate is the corresponding main excitatory neurotransmitter. LÄS MER

  3. 3. Imaging and Quantification of Brain Serotonergic Activity using PET

    Författare :Pinelopi Lundquist; Margareta Hammarlund-Udenaes; Per Hartvig; Gunnar Blomquist; Paul Cumming; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Brain serotonin; Neurotransmitter release; Neurotransmitter synthesis; Positron emission tomography; Tracer validation; Tracer modelling; Farmakokinetik Farmakoterapi;

    Sammanfattning : This thesis investigates the potential of using positron emission tomography (PET) to study the biosynthesis and release of serotonin (5HT) at the brain serotonergic neuron. As PET requires probe compounds with specific attributes to enable imaging and quantification of biological processes, emphasis was placed on the evaluation of these attributes. LÄS MER

  4. 4. Multiple neurotransmitter inputs modulate circadian clock neurons in Drosophila

    Författare :Yasutaka Hamasaka; Dick Nässel; François Rouyer; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; circadian; Drosophila; neurotransmitter; G-protein coupled receptor; Neurobiology; Neurobiologi;

    Sammanfattning : Most animals have endogenous circadian clocks, which drive daily rhythms in behavior and physiology to adapt to daily cycles of the environment. Several sets of neurons have been identified as circadian pacemakers (clocks) in the brain of Drosophila melanogaster, but the neuronal circuits and neurotransmitters signalling circadian information are poorly known. LÄS MER

  5. 5. Applications of nanospray desorption electrospray ionization mass spectrometry : In situ lipid and metabolite analysis from cells to tissue

    Författare :Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Martina Marchetti-Deschmann; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; mass spectrometry imaging MSI ; nanospray desorption electrospray ionization nano-DESI ; single-cell analysis; neurotransmitter imaging; diabetic nephropathy; pneumatic nebulization; lipidomics; metabolomics; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Ambient mass spectrometry (MS) has proved to be an important addition to the bioanalytical toolbox. These methods perform analyte sampling and ionization under atmospheric pressure, and require very little sample preparation other than the sampling process in front of the machine. LÄS MER