Sökning: "spatial metabolomics"

Hittade 4 avhandlingar innehållade orden spatial metabolomics.

1. 1. Spatial metabolomics using Surface Sampling Capillary Electrophoresis Mass Spectrometry  : New tool for direct surface sampling chemical analysis of biological samples

   Författare :Anastasia Golubova; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Analytical surface sampling tools enable direct chemical studies of solid biological samples, including morphologically diverse tissue, and provide both fast chemical analysis with minimum sample preparation and information about molecular spatial distribution. Spatially resolved investigations of tissue sections could help to reveal pathological mechanisms at specific tissue locations. LÄS MER

3. 2. Image-based multi-omics data integration : Exploring whole-body PET/MRI, -omics data and body composition

   Författare :Robin Visvanathar; Håkan Ahlström; Joel Kullberg; Jan Eriksson; Katrine Riklund; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Body composition; Imiomics; genomics; metabolomics; MRI; PET; insulin sensitivity; T2D;

   Sammanfattning : Advanced body composition analysis with whole-body imaging could uncover novel associations between regional tissue composition and metabolic disease. Imiomics is an automated image analysis framework that enables large-scale integration of magnetic resonance imaging (MRI) data and orthogonal technologies such as metabolomics and genomics for the detailed study of body composition. LÄS MER

4. 3. Analytical developments and applications of ambient mass spectrometry imaging : Visualizing challenging analytes and understanding chemical mechanisms of ischemic stroke

   Författare :Leonidas Mavroudakis; Ingela Lanekoff; Daniel Globisch; Malcolm Clench; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry imaging; ischemic stroke; mass spectrometry; isomers; spatial metabolomics; host-guest; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : Bioanalytical methods that provide spatial information on molecular distributions are important for deep understanding of chemical mechanisms in health and disease. For instance, the localized action of drugs and metabolites can provide valuable information on metabolism in specific cellular regions, which would not be possible with bulk analysis. LÄS MER

5. 4. Label free analysis and spatial distribution of molecular lipids in brain tissue and cells using mass spectrometry imaging

   Författare :Amir Saeid Mohammadi; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry Imaging; Secondary Ion Mass Spectrometry Imaging; Matrix Assisted Laser desorption Ionization; Lipids; Brain tissue;

   Sammanfattning : Lipids are important inherent components in brain and cell membranes, which play significant biological roles in cell function. Identification and localization of specific biomolecules such as peptides and lipids within cellular membranes is currently a major challenge in metabolomics and biological studies. LÄS MER