Sökning: "hyperalgesia"

Visar resultat 21 - 25 av 33 avhandlingar innehållade ordet hyperalgesia.

  1. 21. Genetic factors and the role of the NMDA receptor in pain modulation and the effect of opioids

    Författare :Aida Plesan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :pain; NMDA-receptor antagonists; genetic difference; rat strain; opioids; methadone; morphine tolerance; neuropathic pain;

    Sammanfattning : Pain perception and the response to opioid analgesics are determined by a number of factors, among which genetic variability and the activation of the NMDA-receptor for glutamate play an important role. The effects of two clinically available NMDA-receptor antagonists, ketamine (KET) and dextromethorphan (DEX), were evaluated on an animal model of acute nociception, the hot plate test, and on human experimental acute ischemic pain. LÄS MER

  3. 22. Talking to the Brain at the Blood-Brain Barrier through Inflammation-Induced Prostaglandin E2

    Författare :Ana Maria Vasilache; Camilla Nilsberth; Sivert Lindström; Fredrik Elinder; Ted Ebendal; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The immune-to-brain signaling is a critical survival factor when the body is confronted by pathogens, and in particular by microorganisms. During infections, the ability of the immune system to engage the central nervous system (CNS) in the management of the inflammatory response is just as important as its ability to mount a specific immune response against the pathogen, since the CNS can provide a systemic negative feed-back to the immune activation by release of stress hormones and also can prioritize the usage of the energy resources by the vital organs. LÄS MER

  4. 23. Experimental tooth clenching : a model for studying mechanisms of muscle pain

    Författare :Andreas Dawson; Malmö högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tooth clenching; muscle pain; bruxism; Delphi technique; pain measurement; masticatory muscles; experimental pain; proprioceptive allodynia; temporomandibular disorders; serotonin; glutamate; masseter muscle; microdialysis;

    Sammanfattning : “I felt like I’d done three rounds with Mike Tyson…all becauseI was grinding my teeth in my sleep”, så beskrev en patient somintervjuades av Daily Mail i en artikel där det ökade problemet medöverbelastning i käkarna beskrevs, vilket kan leda till tandslitage,muskelsmärta, och frakturer på tandmaterial. Det personliga lidandet,och de ekonomiska kostnaderna för både individ och samhälle ärstort. LÄS MER

  5. 24. Prostaglandin E2 in immune-to-brain signaling

    Författare :David Engblom; Tamas Bartfai; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Upon immune-challenge, signaling from the immune system to the brain triggers an array of central nervous responses that include fever, anorexia, hyperalgesia and activation of the hypothalamus-pituitary adrenal axis. These symptoms are dependent on cytokines produced at the site of inflammation. LÄS MER

  7. 25. Behavioural and neurochemical effects and changes in gene expression in inflammatory and neuropathic pain

    Författare :Eva Schött; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Inflammatory pain; neuropathic pain; pain-related behaviour; weight bearing; preemptive analgesia; immediate early genes; substance P; dynorphin; cholecystokinin; microdialysis;

    Sammanfattning : Chronic pain is a common clinical problem, which causes great suffering, and there is a great need for better analgesic drugs and strategies to counteract the transition of acute pain into chronic pain states. In studies of neurochemical mechanisms in animal models of chronic pain it is important to study also the development of spontaneous pain-related behaviour and sensory abnormalities (i. LÄS MER