Sökning: "Aida Plesan"

Hittade 1 avhandling innehållade orden Aida Plesan.

1. 1. Genetic factors and the role of the NMDA receptor in pain modulation and the effect of opioids

   Författare :Aida Plesan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :pain; NMDA-receptor antagonists; genetic difference; rat strain; opioids; methadone; morphine tolerance; neuropathic pain;

   Sammanfattning : Pain perception and the response to opioid analgesics are determined by a number of factors, among which genetic variability and the activation of the NMDA-receptor for glutamate play an important role. The effects of two clinically available NMDA-receptor antagonists, ketamine (KET) and dextromethorphan (DEX), were evaluated on an animal model of acute nociception, the hot plate test, and on human experimental acute ischemic pain. LÄS MER