Sökning: "hybridisation"

Visar resultat 26 - 30 av 131 avhandlingar innehållade ordet hybridisation.

1. 26. On the neuropeptide mRNA expression following neuropsychopharmacological treatments

   Författare :Olof Zachrisson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholecystokinin; Excitotoxicity; Electroconvulsive; In situ hybridisation; Kainic acid; Lithium; Manic-depressive illness; Neuropeptide Y; Rat brain; Schizophrenia; Seizure; Somatostatin; Substance P; Tachykinin receptor;

   Sammanfattning : In addition to classical neurotransmitters, an increasing number of neuropeptides have been found in the brain. Although neuropeptides may play important roles especially in higher brain functions such as emotion, mood, memory, and learning, most focus has been directed upon classical neurotransmitters and their receptors. LÄS MER

3. 27. Spinal motoneurones and the bulbospinal serotonininergic system in aged rats with behavioral deficits

   Författare :Hans Johnson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :aging; behavior; immunohistochemistry; in situ hybridisation; motoneuron; CGRP; axotorny; GAP-43; neurotrophin receptors; degeneration; axon dystrophy; 5HT TRH; SP; 5HLkA; AADC; serotonintransporter protein; fluoxetine; L-5-HTP;

   Sammanfattning : The expression of neuropeptides, growth-related proteins and neurotrophin receptors were studied in motoneurons of young adult rats and in aged rats with symptoms of neuromuscular incapacities. Also studied were aging-related changes in the descending serotoninergic (5HT) bulbospinal system which constitutes a major afferent pathway to spinal motoneurons. LÄS MER

4. 28. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

   Författare :Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

   Sammanfattning : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. LÄS MER

5. 29. HER2 and TP53 in human breast cancer : studies of methods and prognostic value

   Författare :Jenny Bergqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Breast cancer; HER2; c-erbB-2; TP53; tamoxifen; endocrine resistance;

   Sammanfattning : Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. LÄS MER

7. 30. Genetic Analyses of Bovid Remains and the Origin of Early European Cattle

   Författare :Cecilia Anderung; Anders Götherström; Eske Willerslev; Uppsala universitet; []
   Nyckelord :Molecular genetics; Genetik; Bos taurus; cattle; domestication; aDNA; mtDNA; SNPs;

   Sammanfattning : The aurochs Bos primigenius, extinct since 1627, was the wild progenitor of cattle. It is believed that all European cattle originate from one domestication event in the Near East 10 000 years ago. LÄS MER