Sökning: "granzyme"

Visar resultat 16 - 20 av 43 avhandlingar innehållade ordet granzyme.

  1. 16. Genetic studies of familial hemophagocytic lymphohistiocytosis

    Författare :Kim Göransdotter Ericson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial hemophagocytic lymphohistiocytosis FHL ; PRF1 gene; MUNC13-4 gene; NK cells; cytotoxic T lymphocytes;

    Sammanfattning : The main contribution from this thesis is a refined knowledge of locus heterogeneity in familial hernophagocytic lympbohistiocytosis (FHL) and a further characterization of corresponding clinical and immunological phenotypes. Familial hemophagocytic lymphohistiocytosis is a fatal autosomal recessive immune deficiency clinically characterized by fever, cytopenia, hepatosplenomegaly, and hemophagocytosis. LÄS MER

  3. 17. Molecular monitoring of acute graft-versus-host disease after allogenic stem cell transplantation

    Författare :Marie Jaksch; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Stem Cell Transplantation; Acute Graft-versus-host disease; FasL; Granzym B; Chemokine receptors; chimerism;

    Sammanfattning : Acute graft-versus-host disease (GVHD) remains a major barrier to the wider application of allogeneic stem cell transplantation (SCT) for a variety of diseases. GVHD occurs when the transplanted donor Tlymphocytes react to host antigens on antigen-presenting cells and attack host tissues. LÄS MER

  4. 18. Induction of Mast Cell Apoptosis via Granule Permeabilization : A Novel Approach to Target Mast Cells

    Författare :Aida Paivandy; Gunnar Pejler; Magda Babina; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mast cells; Granules; Apoptosis; Reactive oxygen species; ROS; Lysosomotropic agents; Mefloquine; Immunologi; Immunology; Biokemi; Biochemistry;

    Sammanfattning : Mast cells are densely granulated tissue-resident immune cells that play an important role in orchestrating inflammatory responses. Dysregulated increases in the numbers and activation status of mast cells can have deleterious consequences for the body in various inflammatory diseases. LÄS MER

  5. 19. Early induced immune responses : regulation of dendritic cell and NK cell functions

    Författare :Robert Wallin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cell; Natural killer cell; Cytoskeleton; cAMP; cytotoxicity;

    Sammanfattning : The evolution of the advanced vertebrate adaptive immune system has required co-evolution of sophisticated immune regulating systems that determine immune class of cytokines, antibodies as well as effector mechanisms used by killer cells. The co-ordination of these responses are likely to be carried out by dendritic cells (DC) under the influence of the tissue cells and innate immune cells resident in the tissue from where the DC originates. LÄS MER

  7. 20. Hantaviruses : shedding, stability and induction of apoptosis

    Författare :Jonas Hardestam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hantaviruses are spread and maintained in different rodent and insectivore species worldwide. Humans are believed to be infected mainly by inhalation of aerosolized contaminated rodent excreta. LÄS MER