Sökning: "chimerism"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet chimerism.

  1. 1. Graft-versus-Host Disease: Eosinophils, Chimerism and Clinical Features in Patients Undergoing Allogeneic Hematopoietic Stem Cell or Multivisceral Transplantation

    Författare :Julia Cromvik; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; graft-versus-host disease; eosinophilic granulocyte; intestinal transplantation; multivisceral transplantation; chimerism analysis;

    Sammanfattning : Abstract Graft-versus-host disease (GVHD) is a potentially severe complication that may develop after allogeneic hematopoietic stem cell transplantation (HSCT). It can also occur after transplantation with isolated intestinal grafts or after multivisceral transplantation (MVTX). GVHD is difficult to diagnose. LÄS MER

  3. 2. Umbilical cord blood transplantation : clinical outcome, chimerism development, and in vitro expansion of T-cells for clinical use

    Författare :Sofia Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Umbilical cord blood (UCB) is an alternative graft source in allogeneic hematopoietic stem cell transplantation (HSCT). The unique advantages with UCB as a stem cell source are found in the permissibility for human leukocyte antigen (HLA)-mismatch, rapid availability, and comparatively risk-free graft collection. LÄS MER

  4. 3. Outcome after allogeneic stem cell transplantation with special reference to non-malignant disorders, chimerism and graft cell composition

    Författare :Petter Svenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The outcome for patients undergoing allogeneic stem cell transplantation (HSCT), a treatment for several severe malignant and non-malignant disorders with hematopoietic origin, is a balancing act between beneficiary effects and risk factors. Treatment success is still limited by excessive immune response, such as graft-versus-host–disease (GVHD) and graft failure (GF), or the lack thereof as in malignancy relapse or severe infections. LÄS MER

  5. 4. The challenge of co-existence : from graft-versus-host disease to stable mixed chimerism after allogeneic hematopoietic stem cell transplantation

    Författare :Arwen Stikvoort; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The only curative treatment strategy for many hematologic and inborn immunodeficiency disorders is an allogeneic hematopoietic stem cell transplantation (HSCT). The treatment involves replacing the entire hematopoietic system of the recipient. LÄS MER

  7. 5. Molecular monitoring of acute graft-versus-host disease after allogenic stem cell transplantation

    Författare :Marie Jaksch; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Stem Cell Transplantation; Acute Graft-versus-host disease; FasL; Granzym B; Chemokine receptors; chimerism;

    Sammanfattning : Acute graft-versus-host disease (GVHD) remains a major barrier to the wider application of allogeneic stem cell transplantation (SCT) for a variety of diseases. GVHD occurs when the transplanted donor Tlymphocytes react to host antigens on antigen-presenting cells and attack host tissues. LÄS MER